Blast Injury Outcomes (BIO) Study
Active duty military personnel serving in the current and recent conflicts in Afghanistan and Iraq are frequently exposed to blasts.1,2 Although physical trauma is not unexpected during war fighting, survival from blast-related head injury has become a common occurrence only in recent years. As such, the associated cerebral damage is less well studied and understood.
The Blast Injury Outcomes (BIO) Study is a longitudinal study with the short-term objective of better characterizing multi-modal outcomes in individuals who have sustained a brain injury using a systems medicine approach. Long-term aims include monitoring our participants for signs of emerging systems or associated vulnerabilities. Identification of abnormality profiles for all severity levels of brain injury (from any source) reflects a second long-range goal. Third, we will examine and compare physiology between mTBI with and without persisting symptoms and various co-morbidities. Fourth, we intend to advance diffusion imaging, as well as other types of imaging, for clinical use with the brain injured (and other populations). Finally, we will assess methods of analysis, combination and integration for multi-modal data in search of diagnostic profiles. Increased knowledge of injury patterns and the trajectory associated with brain injury could contribute to better methods of diagnosis, monitoring and, perhaps, treatment.
This investigation has spawned several sub-studies, one of which was the Validation of Brief Objective Neurobehavioral Detectors (BOND) of Mild TBI, which continues. We are collaborating with Harvard/Boston Children's Hospital in the Angiogenic Signaling Signatures Identified in Stress and Trauma (ASSIST) sub-study. Oak Ridge National Laboratory (ORNL) is integrating BIO Study multi-modal data.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Validation of Brief Objective Neurobehavioral Detectors of Mild TBI|
- Modality: Neuroimaging; Primary Outcome Measures: FA, MD, AD, RD [ Time Frame: Every two years ] [ Designated as safety issue: No ]
Biospecimen Retention: None Retained
Biospecimen acquisition has not yet begun.
|Study Start Date:||May 2008|
|Estimated Study Completion Date:||June 2015|
|Estimated Primary Completion Date:||June 2015 (Final data collection date for primary outcome measure)|
Validation study of screening instrument.
As of May 2013, 80 of the planned sample have been recruited and evaluated. Recruitment and enrollment is continuing.
|Contact: Lauren A Roselli||(202) 745-8000 ext 7553||Chapman.Research@va.gov|
|Contact: Julie C Chapman||(202) 745-8000 ext email@example.com|
|United States, District of Columbia|
|VA Medical Center, DC||Recruiting|
|Washington, District of Columbia, United States, 20422|
|Contact: Lauren A Roselli 202-745-8000 ext 7553 Chapman.Research@va.gov|
|Principal Investigator: Julie C. Chapman|
|Principal Investigator:||Julie C. Chapman||VA Medical Center, DC|