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Diagnostic Value of HS-CRP in Stable Angina.

This study has been completed.
Sponsor:
Information provided by:
Shiraz University of Medical Sciences
ClinicalTrials.gov Identifier:
NCT00719992
First received: July 18, 2008
Last updated: NA
Last verified: July 2008
History: No changes posted
  Purpose

The aim of this study was to assess the amount of additive value of HS-CRP levels to a positive exercise tolerance test (ETT) in predicting coronary artery disease (CAD) using coronary angiography as the gold standard. The investigators concluded that HS-CRP can be used as a single predictor of coronary vessel involvement in patients with stable angina and positive ETT.


Condition Intervention
Stable Angina
Positive ETT
 Procedure: coronary angiography

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Diagnostic Value of HS-CRP in Stable Angina Patients With Positive Exercise Test as Compared With Coronary Angiography.

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Shiraz University of Medical Sciences:

Primary Outcome Measures:
  • significant coronary lesion [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • severity of CAD [ Designated as safety issue: No ]

Enrollment: 97
Study Start Date: April 2006
Study Completion Date: August 2007
Primary Completion Date: August 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
positive ETT, High HS-CRP
 Procedure: coronary angiography
effect of level of HS-CRP
Active Comparator: 2
positive ETT, Low HS-CRP
 Procedure: coronary angiography
effect of level of HS-CRP

Detailed Description:

the investigators included 97 patients with positive ETT and stable angina and saw that Hs-CRP is the only predictor of severity of CAD as compared with coronary angiography in stable angina patients.

  Eligibility

Ages Eligible for Study:   43 Years to 64 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Stable angina
  • Positive ETT

Exclusion Criteria:

  • Unability to perform ETT
  • Contraindications for ETT and angiography study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00719992

Locations
Iran, Islamic Republic of
Cardiology Ward Shiraz University of Medical Sciences
Shiraz, Fars, Iran, Islamic Republic of, 51318
Sponsors and Collaborators
Shiraz University of Medical Sciences
Investigators
Study Director: javad kojuri, M.D. Shiraz University of Medical Sciences
  More Information

No publications provided

Responsible Party: Dr Javad Kojuri, Shiraz University of medical sciences
ClinicalTrials.gov Identifier: NCT00719992     History of Changes
Other Study ID Numbers: 4543
Study First Received: July 18, 2008
Last Updated: July 18, 2008
Health Authority: Iran: Ministry of Health

Keywords provided by Shiraz University of Medical Sciences:
Exercise tolerance test
HS-CRP
Coronary angiography
Patients

Additional relevant MeSH terms:
Angina Pectoris
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
 Vascular Diseases
Chest Pain
Pain
Signs and Symptoms

ClinicalTrials.gov processed this record on May 19, 2013