Pain Relief of Metoprolol Versus Metoprolol Plus Morphine in Acute Chest Pain

This study has been completed.
Sponsor:
Collaborator:
AstraZeneca
Information provided by:
Sahlgrenska University Hospital, Sweden
ClinicalTrials.gov Identifier:
NCT00718406
First received: July 16, 2008
Last updated: NA
Last verified: August 2002
History: No changes posted
  Purpose

The primary aim was to evaluate the relief of chest pain during the first 30 minutes among patients who received metoprolol alone as compared with metoprolol plus morphine


Condition Intervention Phase
Acute Coronary Syndromes
Drug: Metoprolol
Drug: metoprolol plus morphine
Phase 4

Study Type: Interventional

Resource links provided by NLM:


Further study details as provided by Sahlgrenska University Hospital, Sweden:

Arms Assigned Interventions
Active Comparator: A
A=metoprolol
Drug: Metoprolol
Active Comparator: B
B=metoprolol plus morphine
Drug: metoprolol plus morphine

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Acute chest pain
  • ECG-signs indicating myocardial ischemia

Exclusion Criteria:

  • Heart rate < 60 beats/min
  • Systolic blood pressure < 110 mmHg
  • High degree AV-block
  • Signs of obstructive pulmonary disease
  • Signs of pulmonary oedema
  • Unwillingness
  • Participation in other studies
  • Long delay between arrival of ambulance and randomisation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00718406

Locations
Sweden
Medical Institution, Dept of Molecular and Clinical Medicine, Sahlgrenska University Hospital
Göteborg, Sweden, SE-413 45
Sponsors and Collaborators
Sahlgrenska University Hospital, Sweden
AstraZeneca
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00718406     History of Changes
Other Study ID Numbers: S203-02
Study First Received: July 16, 2008
Last Updated: July 16, 2008
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by Sahlgrenska University Hospital, Sweden:
Acute coronary syndrome
Chest pain
Betablockers
Morphine
Prehospital phase

Additional relevant MeSH terms:
Acute Coronary Syndrome
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Angina Pectoris
Vascular Diseases
Chest Pain
Pain
Signs and Symptoms
Metoprolol
Metoprolol succinate
Morphine
Anti-Arrhythmia Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Antihypertensive Agents
Sympatholytics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic beta-1 Receptor Antagonists
Adrenergic beta-Antagonists
Adrenergic Antagonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Opioid
Narcotics
Central Nervous System Depressants

ClinicalTrials.gov processed this record on August 27, 2014