Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes
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Purpose
This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated, half received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months. Longer term follow up through the Office Of National Statistics will be performed.
| Condition | Intervention |
|---|---|
|
Acute Coronary Syndromes Coronary Artery Disease |
Behavioral: Educational intervention programme |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Primary Purpose: Health Services Research |
| Official Title: | Prospective Registry of Outcomes and Management of Acute Ischaemic Syndromes |
- Adherence to the educational programme measured by the frequency of use of the evidence based treatments: Aspirin, Heparin, Clopidogrel, Beta blockers, Statins.
- Comparison of investigations and tests
- Use of other treatments
- Counselling for lifestyle changes
- Referral to smoking cessation clinics
- Cardiac rehabilitation
- Compliance to treatment at 6 months
- Comparison of clinical events at 6 months
| Enrollment: | 1340 |
| Study Start Date: | March 2004 |
| Study Completion Date: | November 2005 |
This is a multi-centre UK study designed to evaluate if an educational intervention programme delivered to health care professionals can improve the use of evidence based treatments in the management of patients admitted to hospital with non-ST elevation Acute Coronary Syndrome. A total of 38 centres participated. A cluster randomised method was used and half of centres received the educational intervention. Patients were followed to hospital discharge. Patients were followed up at 6 months and longer term follow up for mortality will be performed through the national databases.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:All patients admitted to the hospital (either through casualty or directly to the wards), with a good clinical history of an acute coronary syndrome with one or more of the following:
- Ischaemic changes on the admission ECG (including patients with bundle branch block)
- Elevated Troponin or cardiac enzymes on admission
- Normal ECGs but with evidence of pre-existing coronary artery disease i.e., evidence of a prior history of MI, coronary revascularisation, coronary angiography demonstrating the presence of significant coronary stenosis or a stress test demonstrating ischaemia (treadmill, echo or nuclear scan)
Written informed consent
Exclusion Criteria:
- Patients with persistent ST elevation >1mm in two or more contiguous leads on the ECG.
- Patients treated with thrombolytic therapy, or for whom thrombolytic therapy was considered on admission.
Contacts and Locations| United Kingdom | |
| University Hospital Aintree | |
| Aintree, United Kingdom | |
| Monklands Hospital | |
| Airdrie, United Kingdom | |
| Antrim Hospital | |
| Antrim, United Kingdom | |
| Barnet General Hospital | |
| Barnet, United Kingdom | |
| Barnsley District General Hospital | |
| BArnsley, United Kingdom | |
| Basildon Hospital | |
| Basildon, United Kingdom | |
| North Hampshire Hospital | |
| Basingstoke, United Kingdom | |
| Royal Victoria Hospital | |
| Belfast, United Kingdom | |
| Mater Infirmorum Hospital | |
| Belfast, United Kingdom | |
| Birmingham Heartlands Hospital | |
| Birmingham, United Kingdom | |
| Bridlington And District Hospital | |
| Bridlington, United Kingdom | |
| The Royal Sussex County Hospital | |
| Brighton, United Kingdom | |
| Cumberland Infirmary | |
| Carlisle, United Kingdom | |
| Leighton Hospital | |
| Crewe, United Kingdom | |
| Darent Valley Hospital | |
| Dartford, United Kingdom | |
| Eastbourne District General Hospital | |
| Eastbourne, United Kingdom | |
| Western Infirmary | |
| Glasgow, United Kingdom | |
| Withybush General Hospital | |
| Haverfordwest, United Kingdom | |
| Altnagelvin Area Hospital | |
| Londonderry, United Kingdom | |
| Luton and Dunstable Hospital | |
| Luton, United Kingdom | |
| Macclesfield District General Hospital | |
| Macclesfield, United Kingdom | |
| Northampton General Hospital | |
| Northampton, United Kingdom | |
| Royal Alexandra Hospital | |
| Paisley, United Kingdom | |
| Pontefract General Infirmary | |
| Pontefract, United Kingdom | |
| Whiston Hospital | |
| Prescot, United Kingdom | |
| Oldchurch Hospital | |
| Romford, United Kingdom | |
| Rotherham District General Hospital | |
| Rotherham, United Kingdom | |
| Hope Hospital | |
| Salford, United Kingdom | |
| University Hospital Of North Tees | |
| Stockton-on-Tees, United Kingdom | |
| University Hospital Of North Staffordshire | |
| Stoke-on-Trent, United Kingdom | |
| Wordsley Hospital | |
| Stourbridge, United Kingdom | |
| Taunton and Somerset Hospital | |
| Taunton, United Kingdom | |
| Torbay Hospital | |
| Torquay, United Kingdom | |
| Pinderfields General Hospital | |
| Wakefield, United Kingdom | |
| West Cumberland Hospital | |
| Whitehaven, United Kingdom | |
| Royal Albert Edward Infirmary | |
| Wigan, United Kingdom | |
| Wrexham Maelor Hospital | |
| Wrexham, United Kingdom | |
| Principal Investigator: | Marcus Flather | Royal Brompton & Harefield NHS Trust, Imperial College London |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00716352 History of Changes |
| Other Study ID Numbers: | MREC/03/10/48 |
| Study First Received: | July 15, 2008 |
| Last Updated: | July 15, 2008 |
| Health Authority: | United Kingdom: National Health Service |
Keywords provided by Royal Brompton & Harefield NHS Foundation Trust:
|
non-ST elevation acute coronary syndrome educational intervention evidence based practice guidelines |
Additional relevant MeSH terms:
|
Coronary Artery Disease Myocardial Ischemia Coronary Disease Acute Coronary Syndrome Heart Diseases Cardiovascular Diseases Arteriosclerosis |
Arterial Occlusive Diseases Vascular Diseases Angina Pectoris Chest Pain Pain Signs and Symptoms |
ClinicalTrials.gov processed this record on June 18, 2013