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Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients (SOM)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2009 by Cliniques universitaires Saint-Luc- Université Catholique de Louvain.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ClinicalTrials.gov Identifier:
NCT00716222
First received: July 15, 2008
Last updated: January 20, 2009
Last verified: January 2009
History of Changes
  Purpose

There is a well-documented relationship between short sleep duration and high body mass index (BMI). The mechanism linking short sleep duration and weight gain is unknown. Current studies in healthy young volunteers have shown that experimental sleep restriction is associated with dysregulation of the neuroendocrine control of appetite and with alterations in glucose metabolism. The goal of our study is to determine the metabolic and hormonal modifications induced by chronic sleep curtailment in obese adolescents and young adults and to observe if short sleep is a negative prognostic factor in their weight evolution.


Condition
Obesity
Sleep Disorders

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Cliniques universitaires Saint-Luc- Université Catholique de Louvain:

Estimated Enrollment: 70
Study Start Date: May 2008
Estimated Study Completion Date: May 2009
Groups/Cohorts
1
Obese adolescent and young adult with sleep disorder
2
Obese adolescent and young adult without sleep disorder
3
Lean adolescent and young adult with sleep disorder

Detailed Description:

The main purpose of the study is investigate whether the concentrations of 2 hormones that regulate appetite (leptin, ghrelin), cytokines (TNF-a, IL-6) and CRP are modified in obese adolescents and young adults who had sleep disorders in comparison to obese adolescents and young adults who sleep longer.

  Eligibility

Ages Eligible for Study:   13 Years to 25 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients of the output clinics in the endocrinology and pediatric endocrinology departments at the university hospital.

Criteria

Inclusion Criteria:

  • 13-25 years old
  • BMI > 30 kg/m2 (If adolescents aged under 18 years: BMI equivalent to a BMI for age and sex to a BMI of 30, according to the Cole et al. obesity criteria).

Exclusion Criteria:

  • Infection
  • Liver disease
  • Chronic inflammatory disease
  • Endocrine disease
  • Use of drugs that alter the sensitivity of insulin
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00716222

Contacts
Contact: Veronique VB Beauloye, PhD +3227641370 Veronique.Beauloye@uclouvain.be

Locations
Belgium
Cliniques Universitaires Saint Luc Recruiting
Brussels, Belgium, 1200
Contact: Veronique VB Beauloye, PhD     +3227641370     Veronique.Beauloye@uclouvain.be    
Sponsors and Collaborators
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Investigators
Principal Investigator: Veronique Beauloye, PhD Cliniques universitaires Saint-Luc
  More Information

No publications provided

Responsible Party: M.D. PhD V Beauloye, Cliniques universitaires Saint-Luc
ClinicalTrials.gov Identifier: NCT00716222     History of Changes
Other Study ID Numbers: B40320084032
Study First Received: July 15, 2008
Last Updated: January 20, 2009
Health Authority: Belgium: Institutional Review Board

Additional relevant MeSH terms:
Sleep Disorders
Parasomnias
Obesity
Overnutrition
Nutrition Disorders
Overweight
 Body Weight
Signs and Symptoms
Nervous System Diseases
Neurologic Manifestations
Mental Disorders

ClinicalTrials.gov processed this record on June 17, 2013