Patterns of Cerebral Activation to Innocuous and Noxious Heat Stimulations in Neuropathic Pain

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2010 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00713024
First received: July 9, 2008
Last updated: June 28, 2010
Last verified: June 2010
  Purpose

Patients with neuropathic pain exhibit hyperalgesia and allodynia. Although both peripheral and central determinants are recognized for the pathophysiological basis of neuropathic pain following peripheral injury, the modulating effect on pain processing in brain by peripheral mechanisms remains elusive. Here, we will systematically compare the sensory symptoms and brain activation to innocuous and noxious thermal stimulation applied to the distal leg, foot dorsum or forearm between patients with peripheral neuropathy and healthy controls. Functional magnetic resonance imaging will be used to define brain activation to somatic stimulation with noxious and innocuous stimuli. The blood-oxygenation-level-dependent signals will be correlated with visual analogue scale scores and sensory and affective components obtained from the Short-Form McGill Pain Questionnaire. Brain activation during thermal stimulation in patients with neuropathic pain will be clarified, and we will also analyze the potential relationships between the topography, quality and intensity of the different painful symptoms (i.e. spontaneous ongoing pain, paroxysmal pain, allodynia, hyperalgesia) and the magnitude and pattern of brain activation during thermal stimulation. This will add in our understanding in the pathophysiology of brain modulation in pain and provide clinically useful message toward the potential therapeutics in the management of neuropathic pain.


Condition
Neuropathic Pain

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Patterns of Cerebral Activation to Innocuous and Noxious Heat Stimulations in Neuropathic Pain

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 150
Study Start Date: January 2008
Estimated Study Completion Date: December 2010
Estimated Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Healthy control subjects
2
Patients having neuropathic pain

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   20 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

We will recruit healthy control subjects and patients having neuropathic pain in the current study.

Criteria

Inclusion Criteria:

  • patients having neuropathic pain
  • healthy control subjects

Exclusion Criteria:

  • subjects with pacemaker implantation
  • patients with neuropsychiatric disorder except neuropathic pain
  • subjects with agoraphobia
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00713024

Contacts
Contact: Sung-Tsang Hsieh, M.D., PhD 886-2-23123456 ext 8182 shsieh@ntu.edu.tw

Locations
Taiwan
Department of Neurology, National Taiwan University Hospital Recruiting
Taipei, Taiwan, 100
Contact: Sung-Tsang Hsieh, MD, PhD    886-2-23123456 ext 8182    shsieh@ntu.edu.tw   
Principal Investigator: Ming-Tsung Tseng, M.D         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Sung-Tsang Hsieh, MD, PhD Department of Neurology, National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: Sung-Tsang Hsieh, Department of Neurology, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00713024     History of Changes
Other Study ID Numbers: 200712022R
Study First Received: July 9, 2008
Last Updated: June 28, 2010
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Pain; Functional neuroimaging; Neuropathy; Thermal sensation

Additional relevant MeSH terms:
Neuralgia
Nervous System Diseases
Neurologic Manifestations
Neuromuscular Diseases
Pain
Peripheral Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on October 29, 2014