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| Sponsor: | University of Alabama at Birmingham |
|---|---|
| Information provided by: | University of Alabama at Birmingham |
| ClinicalTrials.gov Identifier: | NCT00699595 |
Purpose
To investigate if labor pain is affected by mother's hormone levels.
The hormonal effects of pregnancy are well documented. Although differences in pain sensitivity between women and men are partly attributable to social conditioning and to psychosocial factors, many laboratory studies of humans have described sex differences in sensitivity to noxious stimuli, suggesting that biological mechanisms underlie such differences. Some animal studies have suggested that sensitivity to pain decreases during pregnancy because of the progressive activation of endogenous pain inhibitory systems. This effect may be mediated by pregnancy-associated hormones, in particular progesterone.
| Condition |
|---|
|
Pregnancy Progesterone Levels Pregnancy Associated Analgesia |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Hormonal Effects on Pain Perception |
Plasma for progesterone levels
| Estimated Enrollment: | 60 |
| Study Start Date: | September 2008 |
| Estimated Study Completion Date: | May 2011 |
| Estimated Primary Completion Date: | May 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
Term pregnant women
Healthy women scheduled for elective Cesarean section.
|
Eligibility| Ages Eligible for Study: | 19 Years to 45 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Healthy term pregnant women
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Michael Froelich, MD, MS | 205-975-0145 | froelich@uab.edu |
| Contact: Alice Esame, BS BIology | 205-934-4711 | alicee@uab.edu |
| United States, Alabama | |
| University of Alabama at Birmingham | Recruiting |
| Birmingham, Alabama, United States, 35294 | |
| Contact: Alice Esame, BS Biology 205-934-4711 alicee@uab.edu | |
| Principal Investigator: Michael Froelich, MD, MS | |
| Sub-Investigator: Brian T. Torgerson, MD | |
| Principal Investigator: | Michael Froelich, MD, MS | University of Alabama at Birmingham |
More Information
| Responsible Party: | Michael Froelich, MD, University at Alabama at Birmingham |
| ClinicalTrials.gov Identifier: | NCT00699595 History of Changes |
| Other Study ID Numbers: | F070721003 |
| Study First Received: | June 13, 2008 |
| Last Updated: | February 10, 2011 |
| Health Authority: | United States: Institutional Review Board |