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Relationship Between Physical Activity and Stem Cells in Older Adults

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Bilek.Laura, University of Nebraska
ClinicalTrials.gov Identifier:
NCT00690183
First received: June 2, 2008
Last updated: January 16, 2013
Last verified: January 2013
  Purpose

Increased numbers of circulating stem cells and physical activity are both associated with improved health in older persons. This pilot study is the initial step in developing a collaborative, translational research project investigating whether physical activity may in part exert a positive influence on aging via the mobilization of stem cells. The specific aim of this pilot project is to collect preliminary data to explore the relationship between physical activity and stem cell populations found in the blood and to determine the variance in the number of circulating stem cells. We hypothesize that stem cell decrease with age, but that persons who are more physically active will have a higher number of stem cells in the blood. A maximum of 40 persons will be recruited to participate. Persons are eligible to participate if they are age 60 or older, haven't been hospitalized recently, do not have an immunologic or blood disease, do not have an infection, and are not undergoing chemotherapy. Subjects will have 2 visits to the UNMC Clinical Research Center (CRC). The first assessment will include an evaluation of health, physical activity and lifestyle via questionnaires. Height, weight and abdominal girth will be measured, and blood will be drawn for immune and stem cell assessment. Subjects will be given a pedometer and accelerometer to wear daily for 7 days. Subjects will return to the CRC for a second visit at which the pedometer and accelerometer will be returned and blood will be drawn. Stem cell and immune assays will be repeated to evaluate the variability of these measures over time. The correlation between stem cell numbers and physical activity will be analyzed. The data will be used to perform sample size calculations for the development of future studies.


Condition
Aging

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Relationship Between Physical Activity and Stem Cells in Older Adults

Further study details as provided by University of Nebraska:

Primary Outcome Measures:
  • Number of circulating stem cells [ Time Frame: upon enrollment, one week later ] [ Designated as safety issue: No ]
  • physical activity [ Time Frame: upon enrollment ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • alcohol consumption [ Time Frame: upon enrollment ] [ Designated as safety issue: No ]
  • smoking history [ Time Frame: upon enrollment ] [ Designated as safety issue: No ]
  • plasma cytokine levels [ Time Frame: upon enrollment, one later ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Plasma will be retained for cytokine analysis.


Enrollment: 39
Study Start Date: June 2008
Study Completion Date: October 2008
Primary Completion Date: August 2008 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Community Sample of Omaha, NE metro area

Criteria

Inclusion Criteria:

  • 60 years of age or older

Exclusion Criteria:

  • Hospitalization within 2 months prior
  • Immunological disease
  • Hematopoietic disease
  • No current infection
  • No current chemotherapy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00690183

Locations
United States, Nebraska
Clinical Research Center, University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Sponsors and Collaborators
University of Nebraska
Investigators
Principal Investigator: Laura D Bilek, PhD, PT University of Nebraska
  More Information

No publications provided

Responsible Party: Bilek.Laura, Associate Professor, University of Nebraska
ClinicalTrials.gov Identifier: NCT00690183     History of Changes
Other Study ID Numbers: 226-08-EP
Study First Received: June 2, 2008
Last Updated: January 16, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by University of Nebraska:
physical activity
stem cells
lifestyle

ClinicalTrials.gov processed this record on November 25, 2014