Inflammatory Cytokines in Symptom Production in Multiple Myeloma
The goal of this research study is to learn about the pain and/or other symptoms that patients may experience either while you are being monitored by your doctor before a decision is made to start you on treatment for your MM, or during and after treatment for MM, and how these symptoms may affect therapy. A second goal is to learn how differences in genes may affect the symptom burden from cancer and cancer therapy.
Behavioral: Neurocognitive Testing
Behavioral: Neurosensory Testing
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Identifying the Role of Inflammatory Cytokines in Symptom Production in Multiple Myeloma|
- Multiple myeloma module of MDASI (MDASI-MM) Questionnaire [ Time Frame: Baseline with 12 Month Longitudinal Assessment ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Tissue sample by inserting a swab into mouth and rubbing firmly against the inside of cheeck or underneath lower or upper lip for about a minute during a regularly schedule clinic visit.
|Study Start Date:||May 2008|
|Estimated Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
Patients diagnosed with multiple myeloma (MM) complete questionnaires with Neurocognitive Testing and Neurosensory Testing
Questionnaires measuring pain and other symptoms, mood, and quality of life.
Other Name: SurveyBehavioral: Neurocognitive Testing
A neurocognitive exam (tests to check your memory and thinking abilities, for example) will be performed.Behavioral: Neurosensory Testing
Neurosensory testing will be performed to find out how sensitive you are to things such as touch, coolness, warmth, pinprick on the finger, and squeezing of the skin on the finger, hand, or arm.
If you agree to take part in this study, you will complete 5 questionnaires during a regularly scheduled clinic visit. These questionnaires will measure pain and other symptoms, such as your mood and quality of life. You will also be asked to give a tissue sample by inserting a swab into your mouth and rubbing firmly against the inside of your cheek or underneath your lower or upper lip for about a minute at most. Completing the 5 questionnaires and the swab sample collection takes about 30 minutes in total.
This is an investigational study.
Up to 500 patients will take part in the cross-sectional phase of this study. All will be enrolled at MD Anderson.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00688168
|United States, Texas|
|UT MD Anderson Cancer Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Xin Shelley Wang, MD||M.D. Anderson Cancer Center|