Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools (proto nage)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified May 2008 by Laval University.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Laval University
ClinicalTrials.gov Identifier:
NCT00686452
First received: May 26, 2008
Last updated: December 18, 2008
Last verified: May 2008
  Purpose

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

  1. to compare the prevalence of asthma in swimmers and control subjects
  2. to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
  3. to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Condition
Asthma
Airway Hyperresponsiveness

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

Resource links provided by NLM:


Further study details as provided by Laval University:

Primary Outcome Measures:
  • Asthma and airway hyperreactivity prevalence in swimmers [ Time Frame: 3 measurements in the year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Airway inflammation and remodeling in swimmers [ Time Frame: 3 measurements in the year and a bronchial biopsy ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Serum, plasma, bronchial biopsies


Estimated Enrollment: 100
Study Start Date: March 2007
Estimated Study Completion Date: May 2009
Estimated Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Swimmers without AHR
2
Swimmers with asymptomatic AHR
3
Swimmers with symptomatic AHR and use only of beta-2 adrenargic
4
Swimmers with asthma and inhaled corticosteroids
5
Healthy Subjects
6
Healthy subjects with AHR
7
Healthy subjects with symptomatic AHR (asthma) but without treatment

  Eligibility

Ages Eligible for Study:   14 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Swimmers from Quebec swimming school and universities Control from université Laval or secondary School

Criteria

Inclusion Criteria:

  • 14 to 35 years old
  • To swim at least 10h per week
  • For control subjects, non-competitive healthy subjects

Exclusion Criteria:

  • any disease that may interfere with the tests for the controls
  • Triathletes are excluded
  • Smokers
  • Obese or with a BMI more than 29
  • Former athletes (control group)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00686452

Contacts
Contact: Valérie BOUGAULT, PhD 418-656-8711 ext 1507 valerie.bougault@crhl.ulaval.ca
Contact: Louis-Philippe BOULET, MD 418-656-4747 lpboulet@crhl.ulaval.ca

Locations
Canada, Quebec
Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval Recruiting
Québec, Quebec, Canada, G1V4G5
Contact: Valerie BOUGAULT, PhD    418-656-8711 ext 1507    valerie.bougault@crhl.ulaval.ca   
Contact: Louis-Philippe BOULET, MD       lpboulet@crhl.ulaval.ca   
Principal Investigator: Louis-Philippe BOULET, MD         
Sponsors and Collaborators
Laval University
  More Information

No publications provided by Laval University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Dr Louis-Philippe BOULET, MD, Hôpital Laval
ClinicalTrials.gov Identifier: NCT00686452     History of Changes
Other Study ID Numbers: CER20159
Study First Received: May 26, 2008
Last Updated: December 18, 2008
Health Authority: Canada: Canadian Institutes of Health Research

Keywords provided by Laval University:
Asthma
Airway hyperresponsiveness
Swimmers
Airway inflammation
Airway remodelling

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on August 28, 2014