Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment

• Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  

• Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Determine the specific character or not the atrophy and the metabolic modifications of regions under - hippocampiques in the novice Alzheimer's disease. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  
• Inform the existence of process of functional compensation in the population of aMCI, notably to those who show themselves stable or improve. [ Time Frame: 36 months ] [ Designated as safety issue: Yes ]
  

The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.