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Evaluation the Growth Factors(IGF-1,IGFBP-3and HGH)in Patients With Chronic Liver Disease

This study has been completed.
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital Identifier:
First received: May 15, 2008
Last updated: May 16, 2008
Last verified: January 2006

BACKGROUND The insulin-like growth factor system (IGFs) plays an important role in cell growth and differentiation. Nevertheless, the roles played by insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and human growth hormone (HGH) in the progression of chronic liver disease remain to be elucidated and investigated.

METHODS The subjects in the present study included 60 healthy controls, 30 hepatitis patients, 60 liver cirrhosis patients and 60 untreated hepatocellular carcinoma patients. Blood was drawn by venipuncture into Venoject tubes. To find the possible correlations between liver damage and IGFs, serum IGF-1, GH, IGFBP-3 concentration and related biochemical parameters were measured. We used immunoradiometric assay to determine the levels of IGF-1, HGH and IGFBP-3 in serum.

Liver Cirrhosis
Hepatocellular Carcinoma

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Insulin-Like Growth Factor-1,Insulin-Like Growth Factor Binding Protein-3 and Human Growth Hormone in Serum of Patients With Chronic Liver Disease and Possible Clinical Applications.

Resource links provided by NLM:

Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Biospecimen Retention:   Samples Without DNA


Enrollment: 210
Study Start Date: September 2006
Study Completion Date: March 2008
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
three arms for study

Detailed Description:

healthy controls:one blood sample (7.5 cc) hepatitis: three blood samples, at admission, at 3rd and 7-10th day of admission liver cirrhosis: two blood samples, at 1-2 years interval (7.5 cc/each session) hepatocellular carcinoma: three blood samples, before, 1 day after and at the 7th day of transcatheter arterial chembolizatiom


Ages Eligible for Study:   30 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Acute hepatitis liver cirrhosis hepatocellular carcinoma


Inclusion Criteria:

  • Clinical diagnosis of Hepatocellular carcinoma
  • Must be primary Hepatocellular carcinoma and untreament

Exclusion Criteria:

  • treatment Hepatocellular carcinoma
  Contacts and Locations
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Please refer to this study by its identifier: NCT00679692

Division of Radio immunoassay lab,Department of Nuclear Medical University Hospital,No.100 Tzyou 1st Road
Kaohsiung, Taiwan
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Principal Investigator: chiou m Lin, Ms Kaohsiung Medical University
  More Information

No publications provided

Responsible Party: Kaoshing Medical University Chung-Ho Memorial Hospital Identifier: NCT00679692     History of Changes
Other Study ID Numbers: KMUH-IRB-950123, KMUH-IRB-950123
Study First Received: May 15, 2008
Last Updated: May 16, 2008
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Additional relevant MeSH terms:
Carcinoma, Hepatocellular
Liver Cirrhosis
Liver Diseases
Digestive System Diseases
Digestive System Neoplasms
Liver Neoplasms
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Glandular and Epithelial
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions processed this record on November 27, 2014