Study Evaluating the Safety and Effects of MN-221 in Subjects With Moderate to Severe Asthma

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
MediciNova
ClinicalTrials.gov Identifier:
NCT00679263
First received: May 14, 2008
Last updated: December 14, 2011
Last verified: November 2011
  Purpose

The purpose of this study is to evaluate the safety and tolerability of MN-221 at two different dosing rates administered through a continuous infusion in subjects diagnosed with moderate to severe asthma.


Condition Intervention Phase
Asthma
Drug: MN-221
Drug: Placebo
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: A Randomized, Single-blind, Parallel Group, Placebo-controlled, Dose Rate Escalation Study Evaluating the Safety and Effects of MN-221 in Subjects Diagnosed With Moderate to Severe Asthma

Resource links provided by NLM:


Further study details as provided by MediciNova:

Primary Outcome Measures:
  • Number of Patients Reported to Have Adverse Events [ Time Frame: Day 1 to Day 2 ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • FEV1 Percent Predicted Changes From Base Line [ Time Frame: Day 1 to Day 2 ] [ Designated as safety issue: No ]
    The primary efficacy variable will be the change from baseline in FEV1, expressed as percent of predicted at hour 1 after the start of the infusion. Analysis of all other variables at all other time points will be considered secondary.


Enrollment: 17
Study Start Date: February 2008
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: MN-221 Drug: MN-221
Initial dose: 16 μg/min for 15 minutes followed by 8 μg/min for 105 minutes (2-hour infusion with a total dose of 1,080 μg)
Drug: MN-221
Subsequent dose: 30 μg/min for 15 minutes followed by 15 μg/min for 45 minutes (1-hr infusion with a total dose of 1,125 μg).
Placebo Comparator: PLACEBO
Placebo intravenous infusion with dosing volume equivalent to active treatment.
Drug: Placebo
Placebo intravenous infusion with dosing volume equivalent to active treatment.

Detailed Description:

This is a multi-center, randomized, single-blind*, parallel group, placebo-controlled, study with two dosing regimens in subjects diagnosed with moderate to severe asthma using MN-221 or placebo. Subjects will be randomized to receive MN-221 or placebo in a 3:1 ratio, MN-221:placebo. Subjects randomized to receive MN-221 will be dosed with active study drug at both dosing visits, and subjects randomized to the placebo arm will receive placebo at both dosing visits. Approximately 25 subjects diagnosed with moderate to severe asthma who have not received inhaled corticosteroid therapy within one month of Screen Visit 1 will be enrolled and will participate throughout the study.

Initial dose:

  • 16 μg/min for 15 minutes followed by 8 μg/min for 105 minutes (2-hour infusion with a total dose of 1,080 μg MN-221 or Placebo)

Subsequent dose:

  • 30 μg/min for 15 minutes followed by 15 μg/min for 45 minutes (1-hr infusion with a total dose of 1,125 μg MN-221 or Placebo)

There will be approximately a two to four week period between each dose regimen, during which time a safety review will be performed before proceeding to the next dose level. Subjects will be screened for eligibility and continued eligibility will be determined for each subject prior to administering each dose. After the initiation of the intravenous infusion of MN-221 or placebo, serial spirometry will be measured for approximately 24 hours.

For each dose evaluation period, subjects will be domiciled in the clinical research unit (CRU) for 2 nights, beginning on Day -1, one day before dosing. Determination of continued study eligibility will be made on Day -1 for each dose level. Day 1 will include study drug infusion and approximately a 24-hour observation period into Day 2 to allow safety monitoring, serial spirometry, and serum PK measurements. Subjects will be discharged from the CRU on Day 2. They will return to the CRU approximately 2-4 weeks later to participate in the subsequent dose group.

*This is a "modified" single-blind study in which the subject and Investigator are both blinded regarding the treatment arm.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Male or female subjects;
  2. Must sign an informed consent;
  3. Diagnosis of asthma as defined by the American Thoracic Society for at least 3 months;
  4. Must not be receiving inhaled corticosteroids for control within 1 month of study;
  5. Must have an increase in FEV1 of at least 12% and 200 cc over the pre-albuterol FEV1 within 30 minutes after inhalation of up to 4 puffs of albuterol via a metered dose inhaler;
  6. Non-smoker for at least 6 months and in good health;
  7. Female subjects must have a negative pregnancy test;
  8. Male and female subjects of child-bearing potential (not surgically sterile or post menopausal) must be abstinent or agree to use contraceptive regimens throughout the study;
  9. Subjects receiving allergy desensitization therapy can participate as long as they have been on a stable maintenance dose for ≥ 6 months;
  10. Subject must be willing and able not to use inhaled bronchodilators for 6 hours before and until 24 hours after each study drug administration at all study visits; and
  11. Subject must demonstrate mental and physical ability and willingness to follow all study-specific instructions pertaining to the scheduling of study visits and assessments.

Exclusion Criteria:

  1. Have significant cardiopulmonary, renal, hepatic, endocrine, metabolic, neurological or other systemic disease;
  2. Received emergency treatment for asthma within 1 month, or hospitalized for asthma within 3 months;
  3. Had an upper or lower respiratory tract infection within 3 weeks, or sinus infection within 7 days;
  4. Have participated in a clinical study with an investigational drug, other than an MN-221 study, within 30 days;
  5. Have history or evidence of drug or alcohol abuse within 2 years of study entry;
  6. Female subjects who are pregnant or lactating;
  7. Taking any of the following excluded asthma/allergy medications within the time periods indicated prior to the first study visit:

    • Oral, inhaled, or parenteral corticosteroids for 1 month prior to the first study visit.
    • Anti-IgE medication for 3 months prior to the first study visit.
    • Theophylline, long-acting bronchodilators, and anti-cholinergics for 2 weeks prior to the first study visit.
  8. Taking leukotriene modifiers and not on a stable daily dosage for 4 weeks prior to the first study visit.
  9. Taking antihistamines, nasal corticosteroids, or decongestants and not on a stable dose for 3 days prior to any dosing day.
  10. Have a known allergy to MN-221 or any of the other components of the study drug (i.e. lactose);
  11. Have a history of frequent episodes of orthostatic hypotension or any predisposition for orthostatic hypotension;
  12. Have used any prescription or over-the-counter medication, vitamin or herbal supplement (except as listed in Inclusion Criterion 7 and Exclusion Criterion 7-10) within 7 days of study entry, or the expected need to use any unapproved prescription or over-the-counter medication or supplement seven days prior to the first study visit until completion of the study;
  13. Taking any drugs or substances known to be strong inhibitors of cytochrome P450 enzymes within 10 days of study entry, or the expected need to use such drugs ten days prior to the first study visit until after completion of the study;
  14. Taking any drugs or substances known to be strong inducers of cytochrome P450 enzymes within 28 days of study entry, or the expected need to use such drugs prior to completion of the study;
  15. Adhering to any special diet that is not well balanced within 28 days of study entry;
  16. Have donated (standard donation amount or more) blood or blood products (with the exception of plasma noted below) within 56 days of study entry;
  17. Have donated plasma within 7 days of study entry;
  18. Have any laboratory value outside the laboratory reference range that is considered to be clinically significant;
  19. Have any abnormal vital signs (B/P, respiratory rate, heart rate) considered to be clinically significant;
  20. Have positive results for drug and/or alcohol screen;
  21. Have any clinically significant ECG abnormality, including a corrected QT interval (QTc) > 450 msec; and/or
  22. Have any other medical condition or reason that, in the Investigator's opinion, makes the subject unsuitable to participate in this clinical trial.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00679263

Locations
United States, Kansas
PRA International
Lenexa, Kansas, United States, 66219
United States, Massachusetts
Northeast Medical Research Associates
North Dartmouth, Massachusetts, United States, 02747
United States, Missouri
Clinical Research of the Ozarks
Rolla, Missouri, United States, 65401
United States, South Carolina
Greenville Pharmaceutical Research
Greenville, South Carolina, United States, 29615
Sponsors and Collaborators
MediciNova
Investigators
Study Director: Michael Kalafer MediciNova, Inc.
  More Information

No publications provided

Responsible Party: MediciNova
ClinicalTrials.gov Identifier: NCT00679263     History of Changes
Other Study ID Numbers: MN-221-CL-005
Study First Received: May 14, 2008
Results First Received: February 16, 2011
Last Updated: December 14, 2011
Health Authority: United States: Food and Drug Administration

Keywords provided by MediciNova:
asthma
randomized
placebo controlled
dose escalation
safety
efficacy
single blind
MN-221

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on October 01, 2014