A Pilot Study of Acarbose as Treatment for Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD)
Recruitment status was Recruiting
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Purpose
The objective of this study is to demonstrate a reduction of intrahepatic fat as measured with Proton Magnetic Resonance Spectroscopy after 12 weeks administration of oral acarbose. The study will also examine the hypothesis of whether the chronic administration of acarbose in patients with NAFLD will influence postprandial substrate metabolism reflected in the RQ measured by indirect calorimetry.
| Condition | Intervention | Phase |
|---|---|---|
|
Non-Alcoholic Fatty Liver Disease |
Drug: Acarbose |
Phase 2 |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
| Official Title: | A Pilot Study of Acarbose as Treatment for Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD) |
- Improvement of hepatic steatosis as measured by proton magnetic resonance spectroscopy [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
- Postprandial substrate metabolism reflected in the respiratory quotient (RQ) measured by indirect calorimetry [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 12 |
| Study Start Date: | February 2008 |
| Estimated Study Completion Date: | July 2009 |
| Estimated Primary Completion Date: | February 2009 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: 1 |
Drug: Acarbose
50mg tablet by mouth daily for the first 2 weeks, then twice a day for the next 2 weeks, and then three times a day for the next 8 weeks for a total of 12 weeks.
|
Detailed Description:
The chronic administration of acarbose has been shown to improve insulin resistance and reverse impaired glucose tolerance. Both these conditions, especially insulin resistance, are physiologically associated with the development and progression of NAFLD. Therefore, we hypothesized that the chronic administration of acarbose attenuates NAFLD by improving glucose handling. This would be reflected in a reduction of intrahepatic fat accumulation. Proton Magnetic Resonance Spectroscopy is a sensitive and non-invasive method to measure changes in intrahepatic fat content. The primary endpoint of this study would be to demonstrate a reduction of intrahepatic fat as measured with Proton Magnetic Resonance Spectroscopy after 12 weeks administration of oral acarbose. Other relevant secondary outcomes that have been previously demonstrated to be associated with improvement of NAFLD included improvement of insulin resistance, normalizing of serum adiponectin, and a lowering of serum Leptin.
A second intent of the study is to test the hypothesis of whether the chronic administration of acarbose in patients with NAFLD will influence postprandial substrate metabolism reflected in the RQ measured by indirect calorimetry. The consequence of insulin resistance is a relative inhibition of fatty oxidation. However, the chronic administration of acarbose improves insulin resistance and dampens the post-prandial surge in serum glucose and insulin. These changes in glucose handling could possibly result in a shift towards a pattern of preferential lipid oxidation. We anticipate either a lowering or blunting of the postprandial RQ after chronic administration of acarbose for 3 months.
Eligibility| Ages Eligible for Study: | 10 Years to 18 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age:10-18 years old
- Liver biopsy proven NAFLD. NAFLD defined histologically as greater than 5% hepatic macrovesicular steatosis with any degree of chronic inflammation and hepatic fibrosis; clinical definition requires that other liver diseases associated with fatty liver be excluded.
- Insulin resistance with HOMA-IR score >3.0
- Hepatic steatosis >5% wet weight on hepatic proton magnetic resonance spectroscopy (1H-MRS)
- INR <1.2; Conjugated Bilirubin <2umol/L and Albumin >35gm/L
Exclusion Criteria:
- Type 1 or 2 diabetes mellitus
- Treatment with oral hypoglycemic agents
- Ongoing participation in a formal weight loss program or interventional clinical trial
- Panhypopituitarism and genetic causes of obesity i.e. Prader-Willi syndrome
- Alcohol consumption >20 g/day
- Serum creatinine above normal range for age
- History of previous or predisposition to intestinal obstruction
- Pre-existing gastrointestinal disease i.e. inflammatory bowel disease; celiac disease
- Drugs that influence energy metabolism, intestinal transit, substrate metabolism
Contacts and Locations| Contact: Paul B. Pencharz, MD | (416)813-7733 | paul.pencharz@sickkids.ca |
| Canada, Ontario | |
| The Hospital for Sick Children | Recruiting |
| Toronto, Ontario, Canada | |
| Contact: Paul B. Pencharz, MD (416)813-7733 paul.pencharz@sickkids.ca | |
| Sub-Investigator: Eve Roberts, MD | |
| Sub-Investigator: Simon Ling, MD | |
| Sub-Investigator: Jason Yap, MD | |
| Sub-Investigator: Megan Carricato | |
| Principal Investigator: | Paul B. Pencharz, MD | The Hospital for Sick Children |
More Information
No publications provided
| Responsible Party: | Paul Pencharz/Principal Investigator, The Hospital for Sick Children |
| ClinicalTrials.gov Identifier: | NCT00677521 History of Changes |
| Other Study ID Numbers: | 1000011557 |
| Study First Received: | May 12, 2008 |
| Last Updated: | May 12, 2008 |
| Health Authority: | Canada: Health Canada |
Additional relevant MeSH terms:
|
Fatty Liver Liver Diseases Digestive System Diseases Acarbose Enzyme Inhibitors |
Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Hypoglycemic Agents Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on May 16, 2013