Adrenal Exhaustion Syndrome in Critically Ill Patients Without Improvement

This study has been completed.
Sponsor:
Information provided by:
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00674284
First received: May 5, 2008
Last updated: November 23, 2009
Last verified: November 2009
  Purpose

We study the relationship between patient outcomes and sequential changes of serum cortisol level.


Condition
Survival

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Change of Serum Cortisol Levels in Patients Without Improvement in Intensive Care Unit

Further study details as provided by National Taiwan University Hospital:

Enrollment: 80
Study Start Date: February 2008
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Detailed Description:

Elevated corticosteroid level to meet physiologic needs during acute illness is a protective response for stress. This homeostasis is maintained by the hypothalamic-pituitary-adrenal (HPA) axis. However, inadequate response as corticosteroid insufficiency in critically ill patients is reported with increasing frequency, especially in severe sepsis and septic shock. Thus, corticosteroids could be beneficial for septic shock or severe acute illness.

Once considered as normal adrenal function, adrenal insufficiency may developed later with chronic critical illness as adrenal exhaustion syndrome. It is easily overlooked and is possible due to the chronic secretion of systemic cytokines or other HPA axis-suppressive substances. There is still no consensus how often adrenal function testing should be repeated, although a re-evaluation should be considered if clinical symptoms and signs suggest adrenal insufficiency or deteriorating clinical condition.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All of the adult patients (age >18 years) admitted to the intensive care units of the National Taiwan University Hospital between January 2005 and December 2006 were surveyed.

Criteria

Inclusion Criteria:

  • age over 18
  • ICU admission
  • had two cortisol data

Exclusion Criteria:

  • first cortisol data abnormal
  • cortisol data not checked in ICU
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00674284

Locations
Taiwan
Chao-Chi Ho
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Study Director: Chao-Chi Ho, MD 1. Department of Internal Medicine, National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: Chao-Chi Ho, National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00674284     History of Changes
Other Study ID Numbers: 200802022R
Study First Received: May 5, 2008
Last Updated: November 23, 2009
Health Authority: Taiwan: Department of Health

ClinicalTrials.gov processed this record on September 18, 2014