Text Size

Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2008 by Shaare Zedek Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Shaare Zedek Medical Center
ClinicalTrials.gov Identifier:
NCT00671866
First received: April 30, 2008
Last updated: May 4, 2008
Last verified: April 2008
History of Changes
  Purpose

During 1987-1991, WHO supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the Hula Valley. We aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. In adults, we will carry out assays of alkyl phosphates, PON1 (paraoxonase-1), NTE (Neuropathy Target Esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. We will carry out Psycho-Didactic tests in children. The findings will advance knowledge on delayed term health effects of lengthy everyday exposure to OP pesticides and guide regulatory policy.


Condition
Peripheral Neuropathy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Shaare Zedek Medical Center:

Groups/Cohorts
1
Agricultural Workers
2
Non - Agricultural Workers
3
Kibbitz Residents working else where

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Residents of Kibbutzim

Criteria

Inclusion Criteria:

  • Participants of the former study twenty years ago
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00671866

Locations
Israel
Neurology and Toxicology Unit and Service, Shaare Zedek Med Ctr Not yet recruiting
Jerusalem, Israel, 91031
Contact: Yoram Finkelstein, MD PhD     972-2-6555655     yoramf@ekmd.huji.ac.il    
Principal Investigator: Yoram Finkelstein, MD PhD            
Sponsors and Collaborators
Shaare Zedek Medical Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00671866     History of Changes
Other Study ID Numbers: y.finkelstein.ctil.
Study First Received: April 30, 2008
Last Updated: May 4, 2008
Health Authority: Israel: Ministry of Health

Keywords provided by Shaare Zedek Medical Center:
OP
Pesticides
Long-Term Low Level Exposure
Occupational Health
Neurobehavioral Effects

Additional relevant MeSH terms:
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on May 22, 2013