Circulating Endothelium Progenitor Cells and Endogenous Oestrogen in Healthy Subjects (Oestropec)
The purpose of this study is to determine whether the number of circulating EPC is different between healthy women and men.
|Study Design:||Time Perspective: Cross-Sectional|
|Official Title:||Impact of Endogenous Sexual Hormones (Oestrogens and Testosterone) on the Endothelium Circulatory on Rolling at the Young and Old Healthy Volunteer.|
- Number of endothelial progenitor cells by cytometry [ Time Frame: Baseline ] [ Designated as safety issue: No ]
- To compare the number of EPC in young women to older men and menopausal women. To evaluate the correlation between the number of EPC and 17 b-estradiol plasma level. [ Time Frame: Baseline ] [ Designated as safety issue: No ]
Biospecimen Retention: None Retained
whole peripheral blood (150 ml)
|Study Start Date:||April 2006|
|Study Completion Date:||April 2007|
|Primary Completion Date:||April 2007 (Final data collection date for primary outcome measure)|
Non menopausal women
age matched men
age matched men
Study design: Open pilot study in health volunteers in the Hospital Saint-ANTOINE's Clinical Investigation Centre (CIC).
Recruitment and course of the study: The subjects will be recruited among the CIC's pool of healthy volunteers. Volunteer people will then have biological and clinical baseline examinations. If they match the inclusion criteria, an appointment will be taken for the blood sample intend for the characterization of the EPC and hormonal plasma levels evaluation. The participation will not exceed 2 months. Young women will have to come between the 9th and the 11th day after the beginning of menses). A total of 150 ml of peripheral blood will be collected. The study will last 18 months.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00668252
|Assistance Publique Hopitaux de Paris - Hopital Saint Antoine|
|Paris, France, 75012|
|Principal Investigator:||Tabassome Simon, MD - PhD||Assistance Publique Hopitaux de Paris - Université Pierre et Marie Curie Paris 6|