Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

This study has been completed.

First Received on April 18, 2008. Last Updated on April 21, 2008 History of Changes

Sponsor:	Tottori University Hospital
Information provided by:	Tottori University Hospital
ClinicalTrials.gov Identifier:	NCT00664222

Purpose

The purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Condition	Intervention	Phase
Chronic Stable Heart Failure	Drug: spironolactone + furosemide	Phase IV

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment
Official Title:	Effects of Spironolactone on Insulin Resistance in Patients With Chronic Heart Failure

Resource links provided by NLM:

MedlinePlus related topics: Diabetes Medicines Heart Failure

Drug Information available for: Spironolactone Furosemide Insulin Insulin beef

U.S. FDA Resources

Further study details as provided by Tottori University Hospital:

Primary Outcome Measures:

insulin resistance [ Time Frame: 16 weeks ]

Enrollment:	16
Study Start Date:	January 2004
Estimated Study Completion Date:	December 2005

Intervention Details:

spironolactone 25mg/day, 16 weeks and furosemide 20mg/day, 16weeks

Detailed Description:

Diuretics is useful in CHF patients. On the other hand, they deteriorate glucose metabolism. Therefore, the purpose of this study is to evaluate the effects of spironolactone and furosemide on insulin resistance in patients with chronic heart failure.

Eligibility

Genders Eligible for Study:

Both

Criteria

Inclusion Criteria:

chronic stable heart failure

Exclusion Criteria:

renal dysfunction or under treatment with antidiabetic agents

Contacts and Locations

No Contacts or Locations Provided

More Information

No publications provided

Responsible Party:	Kazuhide Ogino, MD, Center for Clinical Residency Program, Tottori University Hospital
ClinicalTrials.gov Identifier:	NCT00664222 History of Changes
Other Study ID Numbers:	#344.1
Study First Received:	April 18, 2008
Last Updated:	April 21, 2008
Health Authority:	Japan: Ministry of Health, Labor and Welfare

Keywords provided by Tottori University Hospital:

heart failure
insulin resistance
inflammatory cytokine
spironolactone
furosemide

Additional relevant MeSH terms:

Heart Failure
Insulin Resistance
Heart Diseases
Cardiovascular Diseases
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Furosemide
Spironolactone
Insulin
Sodium Potassium Chloride Symporter Inhibitors
Membrane Transport Modulators

Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Diuretics
Natriuretic Agents
Physiological Effects of Drugs
Cardiovascular Agents
Therapeutic Uses
Hypoglycemic Agents
Aldosterone Antagonists
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists

ClinicalTrials.gov processed this record on February 12, 2012