Endothelial Dysfunction Induced by Postprandial Lipemia - Full Text View

Sponsor:	Norwegian University of Science and Technology
Information provided by:	Norwegian University of Science and Technology
ClinicalTrials.gov Identifier:	NCT00660491

Purpose

Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Condition	Intervention	Phase
Blood Lipids	Other: exercise training	Phase II

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double Blind (Subject, Caregiver), Crossover Assignment
Official Title:	Endothelial Dysfunction Induced by Postprandial Lipemia: Complete Protection Afforded by High Intensity Aerobic Interval Exercise

Resource links provided by NLM:

MedlinePlus related topics: Exercise and Physical Fitness

U.S. FDA Resources

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:

Flow mediated dilatation [ Time Frame: baseline, post exercise, 30min, 2hour, 4hour post exercise ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

blood lipid profile [ Time Frame: same as flow mediated dilatation ] [ Designated as safety issue: No ]

Estimated Enrollment:	8
Study Start Date:	January 2008
Study Completion Date:	October 2008
Primary Completion Date:	September 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: No Intervention Control
2: No Intervention moderate exercise training group
3: Experimental high intensity exercise group	Other: exercise training moderate intensity exercise group, and high intensity exercise group

Eligibility

Ages Eligible for Study:	20 Years to 40 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion Criteria:

unstable angina, CHD, heart failure,

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00660491

Locations

Norway
NTNU
Trondheim, Norway, 7489

Sponsors and Collaborators

Norwegian University of Science and Technology

Investigators

Study Chair:

Ulrik Wisloff, Professor

NTNU

More Information

No publications provided by Norwegian University of Science and Technology

Additional publications automatically indexed to this study by National Clinical Trials Identifier (NCT ID):

Tyldum GA, Schjerve IE, Tjønna AE, Kirkeby-Garstad I, Stølen TO, Richardson RS, Wisløff U. Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J Am Coll Cardiol. 2009 Jan 13;53(2):200-6.

Responsible Party:	NTNU ( Ulrik Wisloff )
Study ID Numbers:	Exercise, Food and Endothelium
Study First Received:	April 15, 2008
Last Updated:	November 3, 2008
ClinicalTrials.gov Identifier:	NCT00660491 History of Changes
Health Authority:	Norway: The National Committees for Research Ethics in Norway

Keywords provided by Norwegian University of Science and Technology:

flow mediated dilatation
maximal oxygen uptake
blood lipid

ClinicalTrials.gov processed this record on November 20, 2009