Magnetic Resonance (MR) Spectroscopy In Familial Mediterranean Fever (FMF) Patients
Recruitment status was Recruiting
Familial Mediterranean fever (FMF) is an inherited disorder of unknown etiology, characterized by recurrent episodes of fever, peritonitis and/or pleuritis.
Fever is the cardinal manifestation of FMF and is present in most attacks accompanied by abdominal pain.
Another clinical manifestation in patients with FMF is exertional muscle pain, usually in the thigh, which appears even after minor exercise or physical activity in young patients with generally good health (other than FMF) and in good physical condition. Some patients also complain of ankle edema after relatively minor physical activity, which subsides after a night rest. Although these manifestations are quite common in FMF patients and form part of the minor criteria for the diagnosis, the etiopathogenesis has not been examined.
The purpose of the suggested study is to evaluate and characterize the anatomical and biochemical changes in the muscles of the thigh and in the ankle triggered by physical activity in FMF patients complaining of exertional lower leg myalgias and edema after minor physical exercise.
Familial Mediterranean Fever
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||Exertional Muscle Fatigue In FMF Patients Evaluated By MRI And MR Spectroscopy Of The Thigh|
- change in spectroscopic appearance of muscle after exertion of muscle thigh [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
- change in muscle intensity signal after exertion [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
- change in joint effusion status after exertion [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
|Study Start Date:||September 2007|
|Contact: Merav Lidar, MDemail@example.com|
|Sheba Medical Center||Recruiting|
|Ramat Gan, Israel, 52621|
|Contact: Iris Eshed|
|Principal Investigator:||Iris Eshed, MD||Sheba Medical Center|
|Principal Investigator:||Tammi Kushnir, PhD||Sheba Medical Center|