Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2011 by Baycrest.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Dr. Nicole D. Anderson, Baycrest
ClinicalTrials.gov Identifier:
NCT00643266
First received: February 26, 2008
Last updated: September 6, 2011
Last verified: September 2011
  Purpose

We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.

Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.


Condition Intervention
Amnestic Mild Cognitive Impairment
Aging
Behavioral: Recollection Training
Behavioral: Control

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
Official Title: Memory Interventions for Older Adults

Resource links provided by NLM:


Further study details as provided by Baycrest:

Primary Outcome Measures:
  • Recollection estimates [ Time Frame: Immediately post-training and three months post-training ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Brain activation as assessed by functional magnetic resonance imaging [ Time Frame: Immediately post-training ] [ Designated as safety issue: No ]

Estimated Enrollment: 80
Study Start Date: February 2008
Estimated Study Completion Date: March 2012
Estimated Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days
Behavioral: Recollection Training
Participants are exposed to long lists of words. Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality. Participants are instructed to respond "yes" only to words repeated in the same modality. If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.
Other Name: Memory training
Active Comparator: 2
Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants
Behavioral: Control
Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain
Other Name: Educational Control

  Eligibility

Ages Eligible for Study:   65 Years to 90 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 65-90 years old
  • English as a first language or learned before kindergarten
  • Right handed

Exclusion Criteria:

  • Neurologic disorder
  • Major medical disorder affecting cognition
  • Psychiatric disorder
  • Metal in the body that poses a hazard in the MRI scanner
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00643266

Contacts
Contact: Nicole D Anderson, PhD, CPsych 416-785-2500 ext 3366 nanderson@klaru-baycrest.on.ca

Locations
Canada, Ontario
Baycrest Recruiting
Toronto, Ontario, Canada, M6A 2E1
Contact: Nicole D Anderson, PhD, CPsych    416-785-2500 ext 3366    nanderson@klaru-baycrest.on.ca   
Principal Investigator: Nicole D Anderson, PhD, CPsych         
Sponsors and Collaborators
Baycrest
Investigators
Principal Investigator: Nicole D Anderson, PhD, CPsych Baycrest
  More Information

Publications:
Responsible Party: Dr. Nicole D. Anderson, Senior Scientist, Baycrest
ClinicalTrials.gov Identifier: NCT00643266     History of Changes
Other Study ID Numbers: RecollectionTraining, CIHR MOP 67015, ASC 08 95
Study First Received: February 26, 2008
Last Updated: September 6, 2011
Health Authority: Canada: Canadian Institutes of Health Research

Keywords provided by Baycrest:
recollection training
aging
amnestic mild cognitive impairment
fMRI

Additional relevant MeSH terms:
Cognition Disorders
Mild Cognitive Impairment
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on October 22, 2014