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The Effect of Nocturnal Haemodialysis on Arterial Stiffness

This study has been completed.
Sponsor:
Information provided by:
Melbourne Health
ClinicalTrials.gov Identifier:
NCT00641875
First received: March 17, 2008
Last updated: February 3, 2009
Last verified: February 2009
History of Changes
  Purpose

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.


Condition Intervention
End Stage Renal Disease
Arterial Stiffness
 Procedure: Nocturnal Hemodialysis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Melbourne Health:

Primary Outcome Measures:
  • To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis. [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • To examine the relationship between arterial stiffness and clinical and biochemical parameters [ Time Frame: 12 months ] [ Designated as safety issue: No ]

Enrollment: 30
Study Start Date: December 2005
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

All participants are adult patients who are receiving maintenance dialysis at the North West Dialysis Service. Consecutive patients enrolled in the Nocturnal Haemodialysis program are invited to participate in the study

Criteria

Inclusion Criteria:

  • adult dialysis patients
  • able to perform home nocturnal haemodialysis

Exclusion Criteria:

  • age < 18 and > 80 years
  • any patient who is anticipating a live renal transplantation in forthcoming 12 months
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00641875

Sponsors and Collaborators
Melbourne Health
Investigators
Principal Investigator: Michael Lian, FRACP, MBBS Department of Nephrology, Melbourne Health
  More Information

No publications provided

Responsible Party: Dr Michael Lian, Melbourne Health
ClinicalTrials.gov Identifier: NCT00641875     History of Changes
Other Study ID Numbers: 2004.050
Study First Received: March 17, 2008
Last Updated: February 3, 2009
Health Authority: Australia: Human Research Ethics Committee

Keywords provided by Melbourne Health:
arterial stiffness
artery
aortic pulse wave velocity
pulse wave analysis
augmentation index
 end stage renal disease
nocturnal hemodialysis
extended hours of hemodialysis
cardiovascular
hemodialysis

Additional relevant MeSH terms:
Kidney Diseases
Kidney Failure, Chronic
Urologic Diseases
Renal Insufficiency, Chronic
Renal Insufficiency

ClinicalTrials.gov processed this record on May 21, 2013