Right Ventricular Function in Obstructive Sleep Apnea
The purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (OSA) independent from systemic and pulmonary arterial hypertension and their correlation to the severity of OSA.
Sleep Apnea, Obstructive
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||The Evaluation of Subclinical Right Ventricular Dysfunction in Obstructive Sleep Apnea Patients Without Systemic and Pulmonary Arterial Hypertension Using Velocity Vector Imaging|
|Study Start Date:||June 2006|
|Study Completion Date:||June 2008|
|Primary Completion Date:||June 2008 (Final data collection date for primary outcome measure)|
Newly diagnosed obstructive sleep apnea patients without systemic and pulmonary arterial hypertension
Age, sex and and body mass index-matched matched healthy subjects
Many risk factors for OSA, such as male gender, obesity, and increasing age are the same as for cardiovascular diseases. This fact makes it more difficult to establish a causal relationship between OSA and cardiovascular diseases. The relationship between OSA and right ventricular (RV) function is controversial. RV dysfunction may be a result of chronic intermittent hypoxia and hypercapnia during apneic episodes. It may also occur secondary to left ventricular dysfunction as a result of increased afterload and sympathetic activity which causes secondary hypertension. As systemic hypertension is one of the most accompanying and contributing factors in OSA along with obesity, we tried to compare the effects of newly diagnosed OSA on RV function with an age and body mass index- matched control group.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00640536
|Florence Nightingale Hospital|
|Istanbul, Caglayan, Turkey, 34381|
|Principal Investigator:||Saide Aytekin||T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology|