Improve Nuclear Medicine Heart Imaging, Compare MRI Results With Single Photon Emission Computed Tomography Imaging

The recruitment status of this study is unknown because the information has not been verified recently.
Verified December 2009 by State University of New York - Upstate Medical University.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:
NCT00639704
First received: March 12, 2008
Last updated: April 26, 2011
Last verified: December 2009
  Purpose

The purpose of this study is to compare the MRI results with the new SPECT image reconstruction method, this study will allow us to determine whether a new more accurate method of looking at the heart by nuclear study can be used in routine clinical use.


Condition
Cardiac Function

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Evaluation of EM-IntraSPECT Reconstruction Algorithm by Comparison of Transmission Images Reconstructed From SPECT Projections Alone With MRI Studies

Resource links provided by NLM:


Further study details as provided by State University of New York - Upstate Medical University:

Estimated Enrollment: 10
Study Start Date: January 1996
Detailed Description:

Currently, up to one-third of all nuclear medicine studies are performed for cardiovascular disorders, and mostly are myocardial perfusion imaging (MPI) using SPECT acquisition. MPI aims at detection of acute myocardial ischemia and the scarred myocardium and it is increasingly used to plan myocardial revascularization and to assess the effectiveness of medical and surgical interventions. However, nonuniform gamma-ray attenuation in the thoracic region may severely impair the accuracy of SPECT cardiac imaging and frequently result in image artifacts. Therefore, attenuation corrected must be applied. We have derived an algorithm (called EM-IntraSPECT) that is able to reconstruct tomographic cross-sections of a patient from SPECT studies alone. The reconstructed cross-sections in turn, may be used for attenuation correction of cardiac SPECT images thus improving quality analysis based of these images. In this research we intend to continue evaluation of the new attenuation compensation algorithm and to assess the clinical usefulness of this method. These goals can be reached by comparing the patient's cross sectional anatomical data reconstructed by EM-IntraSPECT and obtained from MRI. It is proposed that 10 patients already undergoing nuclear cardiac imaging for clinical purpose, with 99mTc sestamibi or 99mTc radiolabeled red cells will be selected. These patients would be utilized to reconstruct transmission images and determination of internal anatomical structures in the thoracic region from SPECT projections alone. Further, direct and quantitative comparison of the patient's anatomy obtained by the MRI and the SPECT methods will be performed. The same algorithm would be used for reconstruction of attenuation compensated emission SPECT cardiac images. Finally, the accuracy and the clinical usefulness of this new, attenuation corrected cardiac SPECT image reconstruction would be quantitatively evaluated. All these procedures apply only to the image data and NOT the patient.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Subjects who are being evaluated for cardiac function/perfusion

Criteria

Inclusion Criteria:

  • subjects scheduled for cardiac SPECT
  • subjects 18 years old or older

Exclusion Criteria:

  • Females who are pregnant or think that they are pregnant will be excluded in this study.
  • Subjects who have a pacemaker, internal defibrillator, prostheses, artificial heart valves, cardiac stents, surgical clips, or TENS (transcutaneous electric nerve stimulator)
  • Subjects who are 300 lbs and over
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00639704

Contacts
Contact: Susan Hemingway, CCRP 315-464-5099 hemingws@upstate.edu

Locations
United States, New York
SUNY Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Susan Hemingway, CCRP    315-464-5099    hemingws@upstate.edu   
Principal Investigator: Andrzej Krol, PhD         
Sponsors and Collaborators
State University of New York - Upstate Medical University
Investigators
Principal Investigator: Andrzej Krol, PhD State University of New York - Upstate Medical University
  More Information

No publications provided

Responsible Party: Andrzej Krol, PhD, SUNY Upstate Medical University
ClinicalTrials.gov Identifier: NCT00639704     History of Changes
Other Study ID Numbers: SUNYUMU 3257
Study First Received: March 12, 2008
Last Updated: April 26, 2011
Health Authority: United States: Institutional Review Board

Keywords provided by State University of New York - Upstate Medical University:
MRI
SPECT
Cardiac function

ClinicalTrials.gov processed this record on July 26, 2014