Biochemical and Physiological Changes Associated With Differing Durations of Relaxation Response Training
We are looking at the effects of Stress Management and Relaxation Response training on stress hormones (like adrenalin and cortisol), immune function and physiology (heart rate, breathing rate, muscle tension).
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Biochemical and Physiological Changes Associated With Differing Durations of Relaxation Response Training|
Whole blood Serum Plasma
|Study Start Date:||December 2006|
|Study Completion Date:||March 2011|
|Primary Completion Date:||March 2011 (Final data collection date for primary outcome measure)|
Relaxation Response + Stress Management Curriculum
Behavioral: Relaxation Response + Stress Management Curriculum
Subjects will receive 8 weeks of Stress Management curriculum and guidance through 20 minute Relaxation Response with a research coordinator. They will also practice 20 minutes of Relaxation Response at home daily.
The primary aim of this study is to determine whether differing durations of relaxation response (RR) training will be associated with different degrees of change in physiological, psychological, hormonal, molecular and immunological markers. Prior studies have reported reduction on many of these parameters after 8 weeks of RR training. However, we now seek to understand the degree to which incremental decreases in these parameters are exhibited at 0, 4, and 8 weeks of RR practice in 30 healthy adults. Furthermore, we will explore correlations between levels of exhaled nitric oxide or plasma nitrites/nitrates and oxygen consumption during RR elicitation. We will also examine any associations between changes in oxygen consumption and psychological factors, physiological parameters, and biochemical outcomes. Lastly, we will bank plasma and peripheral blood cells from these samples for future assessments of immune markers, cell typing and gene expression.
|United States, Massachusetts|
|Benson-Henry Institute for Mind Body Medicine|
|Boston, Massachusetts, United States, 02114|
|Principal Investigator:||Herbert Benson, MD||Benson-Henry Institute for Mind Body Medicine at Massachusetts General Hosptial|