Efficacy of Vitamin C Injection on Fatigue in Workers After Work

This study has been completed.
Korean Association For Vitamin Research
Information provided by:
DongGuk University
ClinicalTrials.gov Identifier:
First received: March 3, 2008
Last updated: April 8, 2009
Last verified: April 2009

Fatigue is one of the most frequently observed symptoms for company workers, and oxidative stress is regarded as one of its cause. Vitamin C is a well-known antioxidant, and the investigators seek for evidence of the efficacy of high dose vitamin C parenteral supplement on fatigue symptoms of company workers after work.

Condition Intervention Phase
Dietary Supplement: Ascorbic acid (Vitamin C)
Dietary Supplement: Normal saline
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Supportive Care
Official Title: Efficacy of High Dose Vitamin C Parenteral Supplement on Amelioration of Fatigue in Company Workers After Work: A Double-Blind, Randomized Controlled Trial

Resource links provided by NLM:

Further study details as provided by DongGuk University:

Primary Outcome Measures:
  • Degree of fatigue at the point of time with visual analogue scale from 0 to 10 [ Time Frame: Before intravenous vitamin C injection and right after completing injections, and one day later ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Reactive oxygen species [ Time Frame: Before intravenous vitamin C injections, right after completing injections, and one day later ] [ Designated as safety issue: No ]
  • Plasma vitamin C level [ Time Frame: Before intravenous vitamin C injections and right after completing injections ] [ Designated as safety issue: No ]

Enrollment: 150
Study Start Date: March 2008
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Intravenous injections of 10 grams(20ml as a solution) of vitamin C with 100ml of normal saline over 30 minutes.
Dietary Supplement: Ascorbic acid (Vitamin C)
Single intravenous injection of vitamin C 10g(20ml) with 100ml of normal saline over 30 minutes
Other Names:
  • Ascorbic acid
  • Merit C
Placebo Comparator: 2
Intravenous injections of 120ml of normal saline over 30 minutes.
Dietary Supplement: Normal saline
Single intravenous injection of 120ml of normal saline over 30 minutes
Other Name: normal saline

Detailed Description:

Previous studies dealing with vitamin C were focusing on terminal cancer patients or those with chronic fatigue syndrome. Since used drug dosage and the ways of administering vitamin C were not identical, the results were not consistent throughout those studies. This study is aimed to evaluate the efficacy of high dose vitamin C with parenteral supplement on relieving fatigue for apparently healthy volunteers.


Ages Eligible for Study:   20 Years to 49 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Company workers working at least 5 days a week from morning to evening
  • Volunteers who provided written informed consent

Exclusion Criteria:

  • Acute illness
  • Chronic disease such as diabetes, hypertension, liver disease, or renal disease
  • Previous history of renal stone or gout
  • Pregnant or lactating women
  • Hypersensitivity to vitamins or intravenous injections
  • History of vitamin supplements orally or parenterally within 2 days
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00633581

Korea, Republic of
DongGuk University International Hospital
Goyang-si, Gyeonggi-do, Korea, Republic of, 410-773
Sponsors and Collaborators
DongGuk University
Korean Association For Vitamin Research
Principal Investigator: Chang H Yeom, MD, PhD KwanDong University Myungji Hospital
  More Information

Powers SK, Hamilton K. Antioxidants and exercise. Clin Sports Med. 1999 Jul;18(3):525-36

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: ChangHwan Yeom, Kwandong University College of Medicine Myungji Hospital
ClinicalTrials.gov Identifier: NCT00633581     History of Changes
Other Study ID Numbers: DUIH 2008-1-1
Study First Received: March 3, 2008
Last Updated: April 8, 2009
Health Authority: Korea: Food and Drug Administration

Keywords provided by DongGuk University:
ascorbic acid
oxidative stress

Additional relevant MeSH terms:
Signs and Symptoms
Ascorbic Acid
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protective Agents
Physiological Effects of Drugs
Growth Substances

ClinicalTrials.gov processed this record on April 15, 2014