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The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

This study has been completed.
Sponsor:
Information provided by:
Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00632892
First received: March 3, 2008
Last updated: March 10, 2008
Last verified: February 2008
History of Changes
  Purpose

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.

The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).

The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).


Condition
Kidney Diseases

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Far Eastern Memorial Hospital:

Biospecimen Retention:   Samples Without DNA

The urine samples are collected just before and 30 minutes after IVP.The samples are immediately frozen at -80'C until analyzed.


Estimated Enrollment: 80
Study Start Date: December 2007
Primary Completion Date: January 2008 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent
Criteria

Inclusion Criteria:

  1. Adult patients (> 18 years old)
  2. Undergoing IVP with an appropriate medical indication
  3. Signing informed consent

Exclusion Criteria:

1. Without signing informed consent

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00632892

Locations
Taiwan
Far Eastern Memorial Hospital
Pan Chiao, Taipei, Taiwan, 220
Sponsors and Collaborators
Far Eastern Memorial Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00632892     History of Changes
Other Study ID Numbers: 96013
Study First Received: March 3, 2008
Last Updated: March 10, 2008
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Far Eastern Memorial Hospital:
oxidative stress markers in urine
urine norepinephrine
renal tubular enzyme markers

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on May 16, 2013