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Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Michael Sand, Ruhr University of Bochum
ClinicalTrials.gov Identifier:
NCT00630071
First received: February 26, 2008
Last updated: October 15, 2012
Last verified: October 2012
History of Changes
  Purpose

The values of laboratory examinations which are useful for the diagnoses of acute appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR). Another laboratory value which has recently received considerable attention for the early diagnosis of bacterial infection and sepsis is pro-calcitonin (PCT). In recent studies it has been clearly shown that PCT is one of the most important biochemical indicators which closely correlates with the severity of inflammatory host response to microbial infections. Aim of this open, prospective study is therefore to investigate if PCT has an accurate diagnostic value for the diagnosis of acute appendicitis.


Condition
Appendicitis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Study Investigating the Diagnostic Value of Procalcitonin in Patients With Acute Appendicitis

Resource links provided by NLM:

MedlinePlus related topics: Appendicitis
U.S. FDA Resources

Further study details as provided by Ruhr University of Bochum:

Biospecimen Retention:   Samples With DNA

1.5 ml whole blood


Enrollment: 103
Study Start Date: February 2008
Study Completion Date: August 2008
  Eligibility

Ages Eligible for Study:   14 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Surgical Emergency Room

Criteria

Inclusion Criteria:

  • Clinical diagnosis of appendicitis

Exclusion Criteria:

  • Antibiotic therapy
  • Infection at other body sites
  • Age < 14 years
  • Appendectomy in the medical history
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00630071

Locations
Germany
Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum, Germany
Bochum, Germany, 44791
Sponsors and Collaborators
Ruhr University of Bochum
Investigators
Study Chair: Benno Mann, PD Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
Principal Investigator: Michael Sand, Dr. med. Department of General and Visceral Surgery, Augusta Krankenanstalt, Academic Teaching Hospital of the Ruhr-University Bochum
  More Information

Publications:

Responsible Party: Michael Sand, Dr., Ruhr University of Bochum
ClinicalTrials.gov Identifier: NCT00630071     History of Changes
Other Study ID Numbers: PCT 01
Study First Received: February 26, 2008
Last Updated: October 15, 2012
Health Authority: Germany: Ethics Commission

Keywords provided by Ruhr University of Bochum:
Diagnostic Appendicitis
Procalcitonin

Additional relevant MeSH terms:
Appendicitis
Acute Disease
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
 Cecal Diseases
Intestinal Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on May 16, 2013