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Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00630006
First received: February 26, 2008
Last updated: March 5, 2008
Last verified: July 2007
History of Changes
  Purpose

The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease


Condition Intervention
Hepatitis C Virus Infection
Chronic Liver Disease
 Genetic: TNF-alpha and IL-10

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:
  • cytokine gene polymorphism on severity of disease [ Time Frame: years ]

Study Start Date: January 2007
Estimated Study Completion Date: December 2008
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Anti-HCV-positive patients

Exclusion Criteria:

  • Anti-HCV-negative patients
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00630006

Contacts
Contact: Jen-Eing Jeng, M.D. 886-7-3121101 ext 7223 jejeng@cc.kmu.edu.tw

Locations
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.     886-7-3121101 ext 7223     jejeng @cc.kmu.edu.tw    
Principal Investigator: Jen-Eing Jeng, M.D.            
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.     886-7-3121101 ext 7223     jejeng@cc.kmu.edu.tw    
Principal Investigator: Jen-Eing Jeng, M.D.            
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.     886-7-3121101 ext 7223     jejeng@cc.kmu.edu.tw    
Principal Investigator: Jen-Eing Jeng, M,D,            
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Investigators
Principal Investigator: Jen-Eing Jeng, M.D. Assistant Professor
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00630006     History of Changes
Other Study ID Numbers: KMUH-IRB-950182
Study First Received: February 26, 2008
Last Updated: March 5, 2008
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Hepatitis
Hepatitis A
Hepatitis C
Liver Diseases
Virus Diseases
Digestive System Diseases
 Hepatitis, Viral, Human
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections

ClinicalTrials.gov processed this record on May 16, 2013