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Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2007 by Kaohsiung Medical University Chung-Ho Memorial Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00629668
First received: February 26, 2008
Last updated: March 5, 2008
Last verified: July 2007
History of Changes
  Purpose

The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.


Condition Intervention
Chronic Liver Disease
Hepatocellular Carcinoma
 Genetic: TNF-alpha and HBV genotype
Other: TNF-alpha and HBV genotypes

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science

Resource links provided by NLM:

MedlinePlus related topics: Liver Diseases
U.S. FDA Resources

Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:
  • cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:
  • cytokine gene polymorohism on severity of disease [ Time Frame: years ]

Study Start Date: January 2007
Estimated Study Completion Date: December 2007
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • HBV-positive patients

Exclusion Criteria:

  • HBV-negative patients
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00629668

Locations
Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D.     886-7-3121101 ext 7223     jejeng @cc.kmu.edu.tw    
Principal Investigator: Jen-Eing Jeng, M.D.            
Sponsors and Collaborators
Kaohsiung Medical University Chung-Ho Memorial Hospital
Investigators
Principal Investigator: Jen-Eing Jeng, M.D. Assistant Professor of Clinical Laboratory
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00629668     History of Changes
Other Study ID Numbers: KMUH-IRB-940189
Study First Received: February 26, 2008
Last Updated: March 5, 2008
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Carcinoma
Liver Diseases
Carcinoma, Hepatocellular
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
 Digestive System Diseases
Adenocarcinoma
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site

ClinicalTrials.gov processed this record on May 22, 2013