Polymorphisms of Fibrosis-Relating Genes on Outcome of HCV-Related Chronic Liver Disease
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Purpose
Hepatitis C virus (HCV) infection causes different disease spectrum ranging from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma. Evidence indicates that host genetic factor may play a role in determining disease progression. It is known that many cytokine polymorphisms affect disease progressin via increasing hepatic fibrosis that are key factors in progressing liver injury. By combinations of fibrosis-relating gene polymorphisms, this study aims to identify patients with high risk for progressive liver disease. These patients need intensive therapy to decrease morbidity and mortality of chronic HCV-related liver disease.
| Condition | Intervention |
|---|---|
|
Fibrosis Chronic Liver Disease |
Genetic: cytokine Genetic: cytokine polymorphisms Genetic: cytokine polymorphism |
| Study Type: | Interventional |
| Study Design: | Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | Polymorphisms of Fibrosis-Relating Genes on Outcome of HCV-Related Chronic Liver Disease |
- cytokine gene polymorphism on disease severity [ Time Frame: years ] [ Designated as safety issue: No ]
| Enrollment: | 600 |
| Study Start Date: | January 2007 |
| Study Completion Date: | September 2009 |
| Primary Completion Date: | September 2009 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: cytokine polymorphisms, HCV infection
Relate the fibrosis cytokine gene polymorphisms with disease severity of HCV-related chronic liver disease
|
Genetic: cytokine
polymorphisms of fibrosis-relating cytokine were measured to validate the effectiveness of fibrosis in HCV-related chronic liver disease
Other Names:
Genetic: cytokine polymorphisms
Fibrosis-relating cytokine polymorphisms in hepatitis C virus-related chronic liver disease were measured to validate the degree of fibrosis
Other Names:
Genetic: cytokine polymorphism
fibrosis-relating cytokine polymorphism
Other Names:
|
Detailed Description:
Determination of the following fibrosis-relating gene polymorphisms in HCV-related chronic liver disease and HCC will be performed: TNF-α , TNF-β, Factor V Leiden, TGF-β1, PDGF-B gene, Angiotensinogen (AT),Angiotensin converting enzyme (ACE), microsomal epoxide hydrolase (mEH) and glutathione-S-transferase (GST).
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Patients with anti-HCV positive
Exclusion Criteria:
- Anti-HCV-negative patients
Contacts and Locations| Taiwan | |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | |
| Kaohsiung, Taiwan, 807 | |
| Kaohsiung Medical University Chung-Ho Hospital | |
| Kaohsiung, Taiwan, 807 | |
| Principal Investigator: | Jung-Fa Tsai, M.D., Ph.D. | Professor of Medicine |
More Information
No publications provided
| Responsible Party: | Jung-Fa,Tsai (1), Professor of Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00629603 History of Changes |
| Other Study ID Numbers: | KMUH-IRB-950347 |
| Study First Received: | February 26, 2008 |
| Last Updated: | April 17, 2013 |
| Health Authority: | Taiwan: Department of Health |
Keywords provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:
|
hepatitis C virus infection chronic liver disease fibrosis-related cytokine |
Additional relevant MeSH terms:
|
Fibrosis Liver Diseases Pathologic Processes Digestive System Diseases |
ClinicalTrials.gov processed this record on May 16, 2013