Computerized Cognitive Training for Childhood Cancer Survivors
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Purpose
Specific Aim 1: To assess the feasibility and acceptability of a home-based, computerized attention training program with survivors of central nervous system (CNS) impacting pediatric cancer (e.g. acute lymphocyte leukemia [ALL], brain tumors).
Specific Aim 2: To estimate the effect size of this attention training program with survivors of childhood cancer to determine whether a larger-scale clinical trial is warranted.
| Condition | Intervention |
|---|---|
|
Primary Brain Tumor |
Behavioral: Captain's Log Computer Program |
| Study Type: | Interventional |
| Study Design: | Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Supportive Care |
| Official Title: | Computerized Cognitive Training for Childhood Cancer Survivors: A Pilot Study |
- Computer program results [ Time Frame: baseline and study completion ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 12 |
| Study Start Date: | June 2007 |
| Study Completion Date: | October 2010 |
| Estimated Primary Completion Date: | September 2009 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Participate in 12 week computer program.
|
Behavioral: Captain's Log Computer Program
12 Computer Program
|
Detailed Description:
Pediatric patients meeting initial eligibility criteria will be identified through the databases for each clinic (n = approximately 50 survivors in each clinic). A letter explaining the purpose of the study will then be sent to the parents of these patients. Interested parents will be invited to contact study personnel by phone or email for a thorough review of the study and to schedule a screening appointment.
After obtaining written informed consent and assent (from parents and child, respectively), screening procedures will include administration of an abbreviated intellectual test battery, two working memory tasks, and a computerized attention measure to the survivor. Parents will complete questionnaire measures regarding their child's adaptive, behavioral, emotional, and attentional functioning; follow-up interviewing will be conducted to clarify any potential problems identified on the questionnaires. The entire screening procedure is estimated to take approximately 60 minutes for the survivor and 30-45 minutes for parents. To maximize efficiency, a research assistant will complete testing with the child and a psychologist will explain the questionnaire measures to the parent and conduct any follow-up interviewing.
Eligibility| Ages Eligible for Study: | 9 Years to 17 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- A T-score greater than the 75th percentile on either the Cognitive Problems/Inattention or the DSM-IV Inattention subscales of the Conners' Parent Rating Scale
- One or more standard deviations below the mean on the Working Memory Index of the WISC-IV or a Working Memory Index that is one or more standard deviations below the participant's estimated IQ.
These criteria are based on the eligibility criteria used in the largest trial to date of psychostimulant methylphenidate (MPH; commonly known as Ritalin) with survivors of childhood cancer.
Exclusion Criteria:
- Estimated IQ ≤ 70
- Motor, visual, or auditory handicap that prevents computer use
- A diagnosis of attention-deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), depression, autism, or pervasive developmental disorder (PDD)
- Insufficient fluency in English.
Participants who are currently taking stimulant medications (stable dose for at least 30 days) for attentional difficulties, but who meet inclusion criteria will be allowed to participate.
Contacts and Locations| United States, North Carolina | |
| Duke University Health Systems | |
| Durham, North Carolina, United States, 27710 | |
| Principal Investigator: | Kristi Hardy, PhD | Duke University Health System |
More Information
No publications provided
| Responsible Party: | Kristi Hardy, PhD, Duke University Health System |
| ClinicalTrials.gov Identifier: | NCT00629395 History of Changes |
| Other Study ID Numbers: | 00001502 |
| Study First Received: | February 27, 2008 |
| Last Updated: | October 26, 2010 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Duke University:
|
pediatric brain tumor survivors |
Additional relevant MeSH terms:
|
Brain Neoplasms Central Nervous System Neoplasms Nervous System Neoplasms Neoplasms by Site |
Neoplasms Brain Diseases Central Nervous System Diseases Nervous System Diseases |
ClinicalTrials.gov processed this record on May 19, 2013