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Genetic Polymorphysm of Cholesterol 24 S Hydroxylase in Patients With Glaucoma and AMD

This study has been completed.
Sponsor:
Information provided by:
Centre Hospitalier Universitaire Dijon
ClinicalTrials.gov Identifier:
NCT00629044
First received: February 25, 2008
Last updated: March 25, 2011
Last verified: August 2009
History of Changes
  Purpose

The aim of this study is to assess the implicitement of the cholesterol 24 S hydroxylase gene and the 24 S hydroxycholesterol in glaucoma and in age related macular degeneration.


Condition Intervention
Glaucoma
 Biological: Assessing the blood level of cholesterol 24 S Hydroxylase
Biological: Assessing the blood level of cholesterol 24 S hydroxylase
Biological: assessing the blood level of cholesterol 24 S hydroxylase

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Screening
Official Title: Etude du Polymorphysme génétique de la cholestérol 24S Hydroxylase et Des Teneurs en 24S hydroxycholestérol Chez Des Patients Atteints de Glaucome ou de dégénérescence Maculaire liée à l'âge.

Resource links provided by NLM:

MedlinePlus related topics: Cholesterol Glaucoma
U.S. FDA Resources

Further study details as provided by Centre Hospitalier Universitaire Dijon:

Primary Outcome Measures:
  • To know if cholesterol 24 S hydroxylase and 24 hydroxycholesterol are involve in Glaucoma and AMD [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]

Estimated Enrollment: 320
Study Start Date: November 2007
Study Completion Date: January 2011
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: G Biological: Assessing the blood level of cholesterol 24 S Hydroxylase
Comparison of venous blood level of Cholesterol 24 S hydroxylase and 24 hydroxycholesterol in patients with Glaucoma and AMD and in healthy subjects.
Active Comparator: AMD Biological: Assessing the blood level of cholesterol 24 S hydroxylase
Comparison of venous blood level of cholesterol 24 S hydroxylase and 24 hydroxycholesterol in patients with Glaucoma, AMD end in healthy subjects
Active Comparator: Healthy subjects Biological: assessing the blood level of cholesterol 24 S hydroxylase
Comparison of venous blood level of cholesterol 24 S hydroxylase and 24 hydroxycholesterol in patients with glaucoma, AMD and in healthy subjects

  Eligibility

Ages Eligible for Study:   40 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Patient with Glaucoma
  • Patient with AMD
  • Healthy patient

Exclusion Criteria:

  • All patients who use any treatment in order to maintain in normal value their blood cholesterol
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00629044

Locations
France
Ophthalmology Unit CHU Dijon
Dijon, Burgundy, France, 21000
Sponsors and Collaborators
Centre Hospitalier Universitaire Dijon
Investigators
Principal Investigator: Catherine Creuzot-Gracher, MD, PhD CHU Dijon
  More Information

Publications:

Responsible Party: Professor Catherine Creuzot-Garcher, CHU Dijon
ClinicalTrials.gov Identifier: NCT00629044     History of Changes
Other Study ID Numbers: PHRC IR 2006
Study First Received: February 25, 2008
Last Updated: March 25, 2011
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Additional relevant MeSH terms:
Glaucoma
Ocular Hypertension
Eye Diseases

ClinicalTrials.gov processed this record on May 22, 2013