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How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?

This study has been completed.
Sponsor:
Collaborators:
Jefferson Medical College of Thomas Jefferson University
Thomas Jefferson University
Information provided by (Responsible Party):
George L. Spaeth MD, Wills Eye
ClinicalTrials.gov Identifier:
NCT00626847
First received: February 20, 2008
Last updated: December 31, 2012
Last verified: December 2012
History of Changes
  Purpose

Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases. So far, research has only been able to find the genes responsible for glaucoma in a small percentage of people who have glaucoma. The purpose of this project is to study the genes in patients with and without glaucoma to find additional genes that may be responsible for causing glaucoma.


Condition
Primary Open Angle Glaucoma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Nuclear Genetic and Mitochondrial Influences in Glaucoma

Resource links provided by NLM:

MedlinePlus related topics: Glaucoma
U.S. FDA Resources

Further study details as provided by Wills Eye:

Primary Outcome Measures:
  • The investigators will quantify the spectrum of changes in mitochondrial respiration, relative mitochondrial DNA content, and oxidative stress associated with different types of glaucoma. [ Time Frame: one blood draw ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

whole blood


Enrollment: 97
Study Start Date: March 2008
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
Primary Open Angle Glaucoma (POAG)
2
Controls (Normals, patients without glaucoma)

Detailed Description:

Four tubes of blood will be taken from 100 people. Of those, half will have primary open angle glaucoma (POAG) and the other half will be controls (normals), half will be caucasians and the other half will be african americans, half male and half female. All groups will have a routine ophthalmic eye exam, color vision, snellen vision, and visual field done.

  Eligibility

Ages Eligible for Study:   40 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

glaucoma clinic

Criteria

Inclusion Criteria:

  • 40 yrs
  • Caucasian or African American
  • Male or female with POAG, PACG, PXFG,
  • Normal

Exclusion Criteria:

  • Other ophthamic co-morbidities
  • Other ethnic groups
  • Unable to understand and give informed consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00626847

Locations
United States, Pennsylvania
Wills Eye Glaucoma Service
Philadelphia, Pennsylvania, United States, 19107
Sponsors and Collaborators
Wills Eye
Jefferson Medical College of Thomas Jefferson University
Thomas Jefferson University
Investigators
Principal Investigator: George L Spaeth, MD Wills Eye Institute
  More Information

No publications provided

Responsible Party: George L. Spaeth MD, Director Glaucoma Research Center Wills Eye; Director Medical Research and Education Glaucoma Service Foundation Wills Eye; Esposito Research Professor, Thomas Jefferson University, Wills Eye
ClinicalTrials.gov Identifier: NCT00626847     History of Changes
Other Study ID Numbers: IRB#07-826
Study First Received: February 20, 2008
Last Updated: December 31, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Wills Eye:
primary open angle glaucoma
Nuclear Genetics
Mitochondrial DNA
POAG

Additional relevant MeSH terms:
Glaucoma
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases

ClinicalTrials.gov processed this record on May 23, 2013