The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

This study is enrolling participants by invitation only.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00624039
First received: February 18, 2008
Last updated: NA
Last verified: May 2006
History: No changes posted
  Purpose

The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility.


Condition Intervention
Presbyopia
Cataract
Other: UBM with pilocarpine in presbyopia

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Resource links provided by NLM:


Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • ultrasound biomicroscopic findings (ciliary body axial length) [ Time Frame: 2 months before and after surgery ] [ Designated as safety issue: No ]

Enrollment: 15
Study Start Date: May 2006
Estimated Study Completion Date: March 2008
Estimated Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
1
ultrasound biomicrocopic examinations and pilocarpine instillation
Other: UBM with pilocarpine in presbyopia
ultrasound biomicroscopic examination in both eyes 30 minutes after one drop of 2% pilocarpine hydrochloride (Ocucarpine®, Samil Pharm., Seoul, Korea) instillation before and two months after cataract surgery
Other Name: UBM with pilocarpine

Detailed Description:

The functional changes in the ciliary body in presbyopia are not only important in a study of the mechanism for presbyopia but are also a key to various procedures or devices used to restore accommodation. Therefore, it is becoming increasingly important to quantify the in vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before and 2 months after cataract extraction. Images of the ciliary body will be compared visually using Adobe Photoshop 7.0.

  Eligibility

Ages Eligible for Study:   55 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age : same or more than 55 years
  • Patients with senile cataract who are going to get cataract surgery

Exclusion Criteria:

  • Age : less than 55 years
  • Previous ocular disease other than cataract.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00624039

Locations
Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Investigators
Study Director: Changwon Kee, M.D. Department of Ophthalmology, Samsung Medical Center, Ilwon-dong, Kangnam-gu, Seoul, 135-710, Republic of Korea. E-mail: ckee@skku.edu
  More Information

Publications:
Responsible Party: Changwon Kee, Department of Ophthalmology, Samsung Medical Center, Seoul, Korea
ClinicalTrials.gov Identifier: NCT00624039     History of Changes
Other Study ID Numbers: CB2006
Study First Received: February 18, 2008
Last Updated: February 18, 2008
Health Authority: South Korea: Institutional Review Board

Keywords provided by Samsung Medical Center:
presbyopia

Additional relevant MeSH terms:
Presbyopia
Cataract
Refractive Errors
Eye Diseases
Lens Diseases
Pilocarpine
Miotics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Muscarinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on April 17, 2014