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Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Rolf Ziesche, Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT00618137
First received: February 5, 2008
Last updated: August 23, 2012
Last verified: August 2012
History of Changes
  Purpose

The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined clinical and molecular approach. The study has been designed as a prospective, intraindividual pilot in 160 male or female volunteers of the greater Vienna Area over a period of three years for each individual volunteer.


Condition
Pulmonary Disease, Chronic Obstructive

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Longitudinal Assessment of Clinical and Molecular Pathology of Chronic Obstructive Lung Disease and the Possible Influence of Inert Dusts in Working Volunteers of the Greater Vienna Area

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Medical University of Vienna:

Biospecimen Retention:   Samples With DNA

Transbronchial lung biopsies Blood serum


Enrollment: 160
Study Start Date: January 2007
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Community sample of workers from the greater Vienna area

Criteria

Inclusion Criteria:

  • COPD °0-III
  • Workers of the greater Vienna Area
  • Current smokers or ex-smokers

Exclusion Criteria:

  • COPD °IV
  • Bronchial asthma
  • Major cardiovascular diseases, in particular stroke and myocardial infarction with reduced cardiac function
  • Age > 65 years
  • Acute or chronic bronchial infection, in particular bronchiectasis
  • Cancer
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00618137

Locations
Austria
Department of Pulmonary Medicine, Medical University of Vienna
Vienna, Austria, A-1090
Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Lutz H Block, MD Medical University of Vienna
Study Director: Rolf Ziesche, MD Medical University of Vienna
  More Information

No publications provided

Responsible Party: Rolf Ziesche, Associated Professor of Medicine, Medical University of Vienna
ClinicalTrials.gov Identifier: NCT00618137     History of Changes
Other Study ID Numbers: COPD-AUVA
Study First Received: February 5, 2008
Last Updated: August 23, 2012
Health Authority: Austria: Ethikkommission

Keywords provided by Medical University of Vienna:
Chronic obstructive pulmonary disease
Gene expression profiling
Inert dusts
Natural course
Prospective assessment

Additional relevant MeSH terms:
Chronic Disease
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
 Lung Diseases, Obstructive
Disease Attributes
Pathologic Processes
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on May 23, 2013