Laparoscopic Approach to Cervical Cancer (LACC)

Inclusion Criteria:

• Histologically confirmed primary adenocarcinoma, squamous cell carcinoma or adenosquamous carcinoma of the uterine cervix;
• Patients with Histologically confirmed stage IA1 (with lymph vascular invasion), stage IA2, or stage IB1 disease
• Patients undergoing either a Type II or III radical hysterectomy (Piver Classification)
• Patients with adequate bone marrow, renal and hepatic function:
• ECOG Performance Status of 0 or 1.
• Patient must be suitable candidates for surgery.
• Patients who have signed an approved Informed Consent
• Patients with a prior malignancy allowed if > 5 years ago with no current evidence of disease
• Females, aged 18 years or older
• Negative serum pregnancy test within <30 days of surgery in pre-menopausal women and women < 2 years after the onset of menopause

Exclusion Criteria:

• Any histology other than adenocarcinoma, squamous cell carcinoma or adenosquamous carcinoma of the uterine cervix;
• Tumor size greater than 4 cm;
• FIGO stage II-IV;
• Patients with a history of pelvic or abdominal radiotherapy;
• Patients who are pregnant;
• Patients with contraindications to surgery;
• Patients with evidence of metastatic disease by conventional imaging studies, enlarged pelvic or aortic lymph nodes > 2cm; or histologically positive lymph nodes
• Unfit for Surgery: serious concomitant systemic disorders incompatible with the study (at the discretion of the investigator);
• Patients unable to withstand prolonged lithotomy and steep Trendelenburg position
• Patient compliance and geographic proximity that do not allow adequate follow-up