Advanced MRI in Major Depression
Depression is the most common psychiatric disorder.
- 3-5% of a given population has major depression.
- Less than 50% of the depressed in Denmark are diagnosed with major depression.
- 25-50% of the depressed have a relative with major depression-underlying brain pathology?
The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression|
- Differences in morphological and functional cerebral MRI findings in patients suffering from major depression [ Time Frame: 6 months from first MRI in each patient ] [ Designated as safety issue: No ]
|Study Start Date:||March 2008|
|Study Completion Date:||June 2011|
|Primary Completion Date:||December 2009 (Final data collection date for primary outcome measure)|
Ambulant patients with major depression
Other: Magnetic Resonance Imaging
Other Name: 3 Tesla GE Scanner HDx
Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.
MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.
|Aalborg Hospital / Aarhus University Hospital|
|Aalborg, Jutland, Denmark, 9000|
|Principal Investigator:||Elna-Marie B Larsson, Professor||Uppsala University Hospital|