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Examination of the Effects of Four Different Spices on Energy Metabolism

This study has been completed.
Sponsor:
Collaborator:
University of Aarhus
Information provided by:
University of Copenhagen
ClinicalTrials.gov Identifier:
NCT00611156
First received: January 28, 2008
Last updated: February 7, 2008
Last verified: August 2007
History of Changes
  Purpose

The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism.

Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually increase energy expenditure - although not to a large degree.


Condition Intervention
Healthy
 Dietary Supplement: ginger
Dietary Supplement: black pepper
Dietary Supplement: horseradish
Dietary Supplement: mustard
Dietary Supplement: placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Prevention
Official Title: Bioactive Food Ingredients and Energy Metabolism: The Effects of Ginger, Black Pepper, Horseradish and Mustard on Meal-Induced Thermogenesis and Fat Oxidation

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • energy expenditure [ Time Frame: November 2007 ]

Secondary Outcome Measures:
  • blood pressure [ Time Frame: December 2007 ]
  • heart rate [ Time Frame: December 2007 ]
  • VAS-scores for appetite, hunger, fullness, etc. - and palatability [ Time Frame: November 2007 ]
  • tolerance [ Time Frame: November 2007 ]
  • Fat and carbohydrate oxidation [ Time Frame: November 2007 ]
  • Meal-induced thermogenesis [ Time Frame: November 2007 ]

Enrollment: 22
Study Start Date: October 2006
Study Completion Date: June 2007
Arms Assigned Interventions
Experimental: A
Spice
 Dietary Supplement: ginger
added to a brunch meal
Experimental: B
Spice
 Dietary Supplement: black pepper
Added to a brunch meal
Experimental: C
Spice
 Dietary Supplement: horseradish
Added to a brunch meal
Experimental: D
Spice
 Dietary Supplement: mustard
Added to a brunch meal
Placebo Comparator: E
Placebo
 Dietary Supplement: placebo
Added to a bruch meal

Detailed Description:

Several pungent food ingredients, such as chili,and also other bioactive food ingredients, e.g. green tea, have been shown to be able to increase energy expenditure and fat oxidation during the hours following a meal containing the bioactive ingredient. Furthermore, we will also look at the subjects own feelings of appetite and thereby examine whether the appetite is affected by the spicy food. We expect to see some small effects on these parameters.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • male
  • healthy and not use medication (regularly)
  • normal weight
  • non smoker
  • tolerate and like spicy food
  • stable body weight last two months

Exclusion Criteria:

  • increased blood pressure
  • abnormal EKG
  • mental, metabolic and chronic diseases
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00611156

Locations
Denmark
Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg, Denmark, DK-1958
Sponsors and Collaborators
University of Copenhagen
University of Aarhus
Investigators
Study Chair: Arne Astrup, Professor MD Department of Human Nutrition, RVAU
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00611156     History of Changes
Other Study ID Numbers: B228-IHE-2006-NTG
Study First Received: January 28, 2008
Last Updated: February 7, 2008
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics

Keywords provided by University of Copenhagen:
Thermogenesis
Meal-induced thermogenesis
energy expenditure
fat oxidation
bioactive ingredients
 spices
ginger
horseradish
black pepper
mustard

Additional relevant MeSH terms:
Mechlorethamine
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
 Pharmacologic Actions
Antineoplastic Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on May 16, 2013