Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease
Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.
Alcoholic Liver Disease
Chronic Hepatitis C Virus
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease|
plasma and peripheral blood mononuclear cell culture medium.
|Study Start Date:||January 2005|
|Study Completion Date:||January 2008|
|Primary Completion Date:||January 2007 (Final data collection date for primary outcome measure)|
alcoholic liver disease
chronic hepatitis C virus infection
Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.
|Hopital Erasme - Dpt of Gastroenterology|
|Principal Investigator:||Arnaud Lemmers, MD||Erasme Hospital, Gastroenterology Dpt|