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| Sponsors and Collaborators: |
University of California, Irvine Mainz University |
| Information provided by: | University of California, Irvine |
| ClinicalTrials.gov Identifier: | NCT00610402 |
Purpose
Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life.
Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma.
These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.
| Condition |
|
Sturge - Weber Syndrome (SWS) |
| Genetics Home Reference related topics: | Cancer Neurologic Diseases Vascular Diseases |
| MedlinePlus related topics: | Cancer Genetic Disorders Neurologic Diseases Vascular Diseases |
| Study Type: | Observational |
| Study Design: | Case-Only, Prospective |
| Official Title: | Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) |
blood sample tear drop sample
| Estimated Enrollment: | 100 |
| Study Start Date: | July 2007 |
| Estimated Study Completion Date: | July 2009 |
| Estimated Primary Completion Date: | July 2009 (Final data collection date for primary outcome measure) |
The ocular antibody profile in patients with SWS is unknown.The researchers want to study on blood and tear drop samples from patients with SWS to determine the incidence of ocular antibodies in patients with this syndrome.
Eligibility
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
community sample
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| United States, California | |||||
| Beckman Laser Institute Medical clinic | |||||
| Irvine, California, United States, 92612 | |||||
| University of California, Irvine |
| Mainz University |
| Principal Investigator: | John S Nelson, M.D,PhD | Beckman Laser Institute Medical Clinic |
More Information
| Responsible Party: | Beckman Laser Institute, University of California, Irvine ( J. Stuart Nelson, M.D., Ph.D. Associate Director and Medical Director at the Beckman Laser Institute and Medical Clinic ) |
| Study ID Numbers: | NIH-LAMMP P41-RR01192 |
| First Received: | January 25, 2008 |
| Last Updated: | January 25, 2008 |
| ClinicalTrials.gov Identifier: | NCT00610402 |
| Health Authority: | United States: Institutional Review Board |
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