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Association Between Cytokines and Severity of Respiratory Syncytial Virus (RSV)-Induced Illness in the Elderly

This study has been completed.
Sponsor:
Collaborator:
American Academy of Allergy, Asthma, and Immunology
Information provided by:
West Penn Allegheny Health System
ClinicalTrials.gov Identifier:
NCT00609635
First received: January 25, 2008
Last updated: April 3, 2009
Last verified: April 2009
History of Changes
  Purpose

This research study involves studying the genes that may affect how ill you become during respiratory infection with respiratory syncytial virus (RSV). RSV is a virus that often causes common colds.

Cytokines are chemicals that are naturally made by your body. Cytokine levels are increased in some people when they have common colds or wheezing caused by respiratory syncytial virus (RSV). The purpose of this study is to study the genes that may control cytokine levels during infection with RSV in the elderly population.


Condition
Respiratory Syncytial Virus Infections

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Association Between Cytokine Genotype Polymorphisms and Severity of RSV-Induced Illness in the Elderly

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by West Penn Allegheny Health System:

Biospecimen Retention:   Samples With DNA

A buccal brushing (cells collected from the inside of the cheek) will be collected and stored for DNA analysis.


Estimated Enrollment: 300
Study Start Date: November 2007
Study Completion Date: April 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

inpatient or outpatient subjects with respiratory illnesses potentially caused by RSV

Criteria

Inclusion Criteria:

  • Subjects > 65 years of age diagnosed with RSV-induced respiratory illness
  • Diagnosis (based upon ICD-9-CM codes) for pneumonia, upper respiratory illness, bronchitis, COPD, asthma, viral illness, or congestive heart failure (CHF)
  • Willing to sign informed consent.

Exclusion Criteria:

  • Not willing to sign informed consent.
  • Subjects less that 65 years of age
  • Subjects not diagnosed with a respiratory illness
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00609635

Locations
United States, Pennsylvania
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Sponsors and Collaborators
West Penn Allegheny Health System
American Academy of Allergy, Asthma, and Immunology
Investigators
Principal Investigator: Ritu Pabby, MD West Penn Allegheny Health System
  More Information

No publications provided

Responsible Party: Ritu Pabby, MD, Allegheny General Hosptial Dept. of Allergy, Asthma, & Immunology
ClinicalTrials.gov Identifier: NCT00609635     History of Changes
Other Study ID Numbers: Adult RSV RC# 4212
Study First Received: January 25, 2008
Last Updated: April 3, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by West Penn Allegheny Health System:
Respiratory
RSV-induced respiratory illness

Additional relevant MeSH terms:
Respiratory Syncytial Virus Infections
Virus Diseases
Pneumovirus Infections
 Paramyxoviridae Infections
Mononegavirales Infections
RNA Virus Infections

ClinicalTrials.gov processed this record on June 18, 2013