Clubfoot DNA Repository
To build a DNA repository to enable participation in ongoing and future Clubfoot genetic linkage studies.
|Study Design:||Observational Model: Family-Based
Time Perspective: Prospective
|Official Title:||Clubfoot DNA Repository|
- To identify a gene, or genes, that are associated with isolated clubfoot. [ Time Frame: 10 years ] [ Designated as safety issue: No ]
- New or improved ways to determine individuals and families at higher risk for clubfoot and development of new or improved ways to treat clubfoot. [ Time Frame: 10 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Each of the study participants (affected and non-affected individuals) will be asked to provide DNA from a blood sample. A 10cc sample of blood will be removed on 1 or 2 occasions by drawing blood from the arm or by finger stick by research staff. If the participant is a child who will be undergoing surgery, the blood sample will be collected at that time to eliminate additional stick. If collecting a blood sample is not possible we can also obtain DNA by collecting a saliva sample. This second technique does not give us as much DNA as we would get from blood. Therefore, if we get saliva samples, we might require more than one saliva sample over the course of the study.
|Study Start Date:||January 2008|
|Estimated Study Completion Date:||January 2018|
|Estimated Primary Completion Date:||January 2018 (Final data collection date for primary outcome measure)|
Clubfoot is a birth defect that can occur alone (in isolation) or as a part of a disease like cerebral palsy (CP). Genetic linkage is a research tool in which DNA samples are tested for genetic landmarks (markers) whose location on chromosomes is known. Genes and markers that are physically close to one another on the chromosome are said to be tightly linked than genes and markers that are located far apart. This gives clues of where to search for genes causing isolated clubfoot. If there appears to be a high correlation between family members' inheritance of a particular marker, and their inheritance of the trait being studied (in this case clubfoot), the area of the chromosome near that marker can then be searched for a likely gene which causes the trait. It is hoped that genetic linkage research might eventually result in new or improved ways to determine individuals and families at higher risk for clubfoot and development of new or improved ways to treat clubfoot.
Our research staff will obtain information about each subject and their family called a pedigree. We will then administer a one page questionnaire to the mother(s) of the affected individual(s). This questionnaire will ask about the mother's experiences during pregnancy (e.g. Did she take multivitamins? Did she smoke or drink? etc.)
Each of the study participants (affected and non-affected individuals) will be asked to provide DNA from a blood sample. If collecting a blood sample is not possible we can also obtain DNA by collecting a saliva sample.
Samples for DNA processing will be stored according to the following repository guidelines. Patient/donor-subject information, questionnaires, and consents will be maintained by the orthopaedic research coordinator.
Samples will be made to investigators not affiliated with UT Southwestern who wish to study genetic factors that cause clubfoot; for example, we have recently been approached by Jacqueline Hecht (UT Health Science Center, Houston) and Matthew Dobbs (Washington University, St. Louis) regarding participation in their multicenter trials. Samples will be de-identified and will include no personal information which would link the sample to the donor subject.
Primary investigator and sub-investigators will determine how samples will be used and by whom. Additional research utilizing subjects' samples will be approved by the TSRHC Research Advisory panel and the IRB at UT Southwestern.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00607191
|Contact: Cindy Danielfirstname.lastname@example.org|
|Contact: Tara Kristof, B.A.||email@example.com|
|United States, Texas|
|Texas Scottish Rite Hospital for Children||Recruiting|
|Dallas, Texas, United States, 75219|
|Principal Investigator: B. Stephens Richards, M.D.|
|Sub-Investigator: John A Herring, M.D.|
|Sub-Investigator: Carol Wise, PhD|
|Sub-Investigator: Charles E Johnston, MD|
|Sub-Investigator: John G Birch, MD|
|Sub-Investigator: Lori A Karol, MD|
|Sub-Investigator: Karl E Rathjen, MD|
|Sub-Investigator: Daniel J Sucato, MD|
|Sub-Investigator: Shawne Faulks, RN, MSN, CNS|
|Principal Investigator:||B. Stephens Richards, M.D.||Assistant Chief of Staff, Texas Scottish Rite Hospital for Children|