Role of Pancreatic Triglyceride Content in Beta-cell Function
This study has been completed.
Sponsor:
University of Texas Southwestern Medical Center
Collaborator:
Information provided by (Responsible Party):
Ildiko Lingvay, University of Texas Southwestern Medical Center
ClinicalTrials.gov Identifier:
NCT00602953
First received: October 25, 2007
Last updated: January 22, 2013
Last verified: January 2013
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Purpose
The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the pancreas (insulin secretion).
| Condition | Intervention |
|---|---|
|
Obesity Type 2 Diabetes |
Other: No intervention planned. |
| Study Type: | Observational |
| Study Design: | Time Perspective: Cross-Sectional |
| Official Title: | Role of Pancreatic Triglyceride Content in Beta-cell Function |
Resource links provided by NLM:
Further study details as provided by University of Texas Southwestern Medical Center:
Primary Outcome Measures:
- Association between panctreatic triglyceride and beta-cell function [ Time Frame: August/2012 ] [ Designated as safety issue: No ]To evaluate the association between pancreatic triglyceride (TG) content measured by the magnetic resonance spectroscopy (MRS) technique and beta-cell function as measured by frequently sampled intravenous glucose tolerance test (FSIVGTT) in volunteers with a wide range of body mass index (BMI).
| Enrollment: | 101 |
| Study Start Date: | September 2007 |
| Study Completion Date: | August 2012 |
| Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Healthy volunteers
Normal weight and normal glucose tolerance.
|
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
|
|
Pre-diabetes
Impaired fasting glucose of impaired glucose tolerance.
|
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
|
|
Overweight
Overweight or obese volunteers, but with normal fasting and postprandial glucose levels.
|
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
|
|
Type 2 diabetes
Patients with type 2 diabetes.
|
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
|
|
Type 1 diabetes
Patients with type 1 diabetes.
|
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
|
Eligibility| Ages Eligible for Study: | 21 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
We enroll adult volunteers of all ethnicities who have no contraindications to the study procedures or use medications that interfere with our measurements.
Criteria
Inclusion Criteria:
- adults without prior history of pancreatic disease (other than diabetes)
Exclusion Criteria:
- use of unapproved medications
- contraindications to the MRI procedure
- contraindications to frequent blood draws
- pregnancy
- use of more than 2 alcoholic drinks/day
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00602953
Locations
| United States, Texas | |
| UT Southwestern Medical Center | |
| Dallas, Texas, United States, 75390 | |
Sponsors and Collaborators
University of Texas Southwestern Medical Center
Investigators
| Principal Investigator: | Ildiko Lingvay, MD, MPH, MSCS | UT Southwestern Medical Center |
More Information
No publications provided
| Responsible Party: | Ildiko Lingvay, MD, MPH, MSCS, University of Texas Southwestern Medical Center |
| ClinicalTrials.gov Identifier: | NCT00602953 History of Changes |
| Other Study ID Numbers: | 042007-021, 1K23RR02447001 |
| Study First Received: | October 25, 2007 |
| Last Updated: | January 22, 2013 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Diabetes Mellitus, Type 2 Obesity Diabetes Mellitus Glucose Metabolism Disorders Metabolic Diseases Endocrine System Diseases |
Overnutrition Nutrition Disorders Overweight Body Weight Signs and Symptoms |
ClinicalTrials.gov processed this record on May 19, 2013