Role of Pancreatic Triglyceride Content in Beta-cell Function

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Ildiko Lingvay, University of Texas Southwestern Medical Center
ClinicalTrials.gov Identifier:
NCT00602953
First received: October 25, 2007
Last updated: January 22, 2013
Last verified: January 2013
  Purpose

The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the pancreas (insulin secretion).


Condition Intervention
Obesity
Type 2 Diabetes
Other: No intervention planned.

Study Type: Observational
Study Design: Time Perspective: Cross-Sectional
Official Title: Role of Pancreatic Triglyceride Content in Beta-cell Function

Resource links provided by NLM:


Further study details as provided by University of Texas Southwestern Medical Center:

Primary Outcome Measures:
  • Association between panctreatic triglyceride and beta-cell function [ Time Frame: August/2012 ] [ Designated as safety issue: No ]
    To evaluate the association between pancreatic triglyceride (TG) content measured by the magnetic resonance spectroscopy (MRS) technique and beta-cell function as measured by frequently sampled intravenous glucose tolerance test (FSIVGTT) in volunteers with a wide range of body mass index (BMI).


Enrollment: 101
Study Start Date: September 2007
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy volunteers
Normal weight and normal glucose tolerance.
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
Pre-diabetes
Impaired fasting glucose of impaired glucose tolerance.
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
Overweight
Overweight or obese volunteers, but with normal fasting and postprandial glucose levels.
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
Type 2 diabetes
Patients with type 2 diabetes.
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.
Type 1 diabetes
Patients with type 1 diabetes.
Other: No intervention planned.
This is a cross-sectional observational study, no intervention is planned.

  Eligibility

Ages Eligible for Study:   21 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

We enroll adult volunteers of all ethnicities who have no contraindications to the study procedures or use medications that interfere with our measurements.

Criteria

Inclusion Criteria:

  • adults without prior history of pancreatic disease (other than diabetes)

Exclusion Criteria:

  • use of unapproved medications
  • contraindications to the MRI procedure
  • contraindications to frequent blood draws
  • pregnancy
  • use of more than 2 alcoholic drinks/day
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00602953

Locations
United States, Texas
UT Southwestern Medical Center
Dallas, Texas, United States, 75390
Sponsors and Collaborators
University of Texas Southwestern Medical Center
Investigators
Principal Investigator: Ildiko Lingvay, MD, MPH, MSCS UT Southwestern Medical Center
  More Information

No publications provided

Responsible Party: Ildiko Lingvay, MD, MPH, MSCS, University of Texas Southwestern Medical Center
ClinicalTrials.gov Identifier: NCT00602953     History of Changes
Other Study ID Numbers: 042007-021, 1K23RR02447001
Study First Received: October 25, 2007
Last Updated: January 22, 2013
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Obesity
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on April 17, 2014