Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa

This study has been completed.
Sponsor:
Information provided by:
Istanbul University
ClinicalTrials.gov Identifier:
NCT00602264
First received: January 15, 2008
Last updated: January 25, 2008
Last verified: January 2008
  Purpose

The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.


Condition
Anorexia Nervosa
Adipokines

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Adipocytokine and Ghrelin Concentrations in Different Stages of Anorexia Nervosa

Further study details as provided by Istanbul University:

Enrollment: 41
Study Start Date: February 2006
Study Completion Date: May 2007
Groups/Cohorts
1
Treatment-naïve patients with a recent diagnosis of anorexia nervosa
2
The weight recovered subgroup of group 1
3
Recovered patients with a previous history of anorexia nervosa but normal menstrual cycles and body weight at the present time
4
Control group

Detailed Description:

Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal menstrual cycles and body weight at the present time (n:10), Group 4: Control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body composition was determined by bioimpedance analysis.

  Eligibility

Ages Eligible for Study:   16 Years to 32 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients with anorexia nervosa and constitutionally thin healthy subjects

Criteria

Inclusion Criteria:

  • Diagnosis of anorexia nervosa for Group 1-3
  • Constitutionally thin healthy subjects for Group 4

Exclusion Criteria:

  • Medical or psychiatric diagnosis other than anorexia nervosa,
  • History of gastrointestinal disease for Group 1-3
  • History of eating disorder or gastrointestinal or psychiatric disease for control group
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00602264

Locations
Turkey
Istanbul Univetsity, Istanbul Medical Faculty, Department of Psychiatrics
Istanbul, Turkey
Sponsors and Collaborators
Istanbul University
Investigators
Study Director: Ayse Kubat Uzum, M.D Istanbul University Istanbul Medical Faculty Department of Endocrinology and Metabolism
Principal Investigator: Basak Yucel, Professor Istanbul University Istanbul Medical Faculty Department of Psychiatrics
Study Chair: Beyhan Omer, Professor Istanbul University Istanbul Medical Faculty Department of Biochemistry
Study Director: Nese Colak Ozbey, Professor Istanbul University Istanbul Medical Faculty Department of Endocrinology and Metabolism
  More Information

No publications provided

Responsible Party: Basak Yucel, Istanbul University Istanbul Medical Faculty Department of Psychiatrics
ClinicalTrials.gov Identifier: NCT00602264     History of Changes
Other Study ID Numbers: 503/5052006, 2005/1795
Study First Received: January 15, 2008
Last Updated: January 25, 2008
Health Authority: Turkey: Ethics Committee

Keywords provided by Istanbul University:
Anorexia nervosa
Adipokines
Ghrelin
Fat mass

Additional relevant MeSH terms:
Anorexia
Anorexia Nervosa
Signs and Symptoms, Digestive
Signs and Symptoms
Eating Disorders
Mental Disorders

ClinicalTrials.gov processed this record on September 22, 2014