Normative High-frequency MEG Database for Children

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2012 by Children's Hospital Medical Center, Cincinnati.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
University of Cincinnati
Information provided by (Responsible Party):
Jing Xiang, Children's Hospital Medical Center, Cincinnati
ClinicalTrials.gov Identifier:
NCT00600717
First received: June 14, 2007
Last updated: February 8, 2012
Last verified: February 2012
  Purpose

The objective of this study is to characterize the normal neuromagnetic profile of sensorimotor, auditory, visual, and language cortices in children and adults using magnetoencephalography (MEG). We hope to build the world's first high-frequency MEG data for the developing brain. High-frequency neuromagnetic signals are associated with high-frequency oscillations (HFOs), ripple, fast ripple or high-gamma activation in the brain.

MEG is a new powerful tool for noninvasively measuring neuromagnetic signals originating from the brain. Since MEG can detect neuromagnetic signals with high spatial and temporal resolution, many brain properties can be studied. For pediatric purposes, MEG can (1) evaluate the functionalities of the sensorimotor, auditory, visual, and language systems non-invasively during normal maturation; (2) identify abnormalities in these functionalities that occur with neurological or neurodevelopmental disorders; and (3) provide a pre-operative "functional map" for neurosurgeons to improve surgical outcomes and decrease morbidity and mortality.

Previously MEG has been used to provide a single three-dimensional point that estimates the 'center' of cortical regions [1,2]. In this study three new techniques will be used to extend the usefulness of MEG beyond this point-like estimate of a cortical primary sensory input or motor output region. The three new techniques are independent component analysis, S-transform, and magnetic spatial filtering. The three new techniques for data analysis will be used in conjunction with non-invasive MEG data collection. The three techniques will provide us with the following important information about the brain: (1) the patterns of synchronization and de-synchronization of evoked cortical activation and (2) the volumetric extent of these active sensorimotor, auditory, visual and language cortices in children and adults. This approach may lead to a new way to study the brain functions in normal children and in children with various brain disorders.


Condition
Healthy

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Localizing Sensorimotor, Auditory, Visual and Language Cortices With Magnetoencephalography

Resource links provided by NLM:


Further study details as provided by Children's Hospital Medical Center, Cincinnati:

Estimated Enrollment: 120
Study Start Date: November 2006
Estimated Study Completion Date: July 2012
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Healthy Children
This normative study recruit healthy children.

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   6 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Since this study focuses on normal MEG data, only normal subjects will be studied. Since women, girls, and minorities are included in the population to whom recruiting materials are directed, we anticipate that subject selection will be equitable.

Criteria

Inclusion Criteria:

  • Healthy and cooperative
  • Ages 6-18 (male or female)
  • Normal hearing and vision
  • Normal hand movement
  • No history for neurological or psychiatric disease
  • No family history for genetic neurological or psychiatric diseases.
  • No metal implants such as pacemaker, neuron-stimulator, cochlear device, etc.

Exclusion Criteria:

  • If you are taking any medications for depression, neurologic, or psychiatric condition
  • If you do not feel well, have epilepsy or other brain disorders
  • If you have had a recent concussion or head injury
  • If you have any metal, such as dental braces, in your body that would cause "magnetic noise", you may not be able to be in this study. If you would like, we can do a simple, quick "magnetic noise screening" in the MEG Center, which can tell us whether you can be in the study.
  • If you have any electrical or metal implants such as pacemakers, neuro-stimulators, or orthopedic pins or plates. The research nurse will discuss all exclusions with you in further detail before the magnetic resonance imaging (MRI) scan.
  • If you could not pass the pre-experimental screening
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00600717

Contacts
Contact: Jing Xiang, PhD 5137225844 Jing.xiang@cchmc.org
Contact: Jing Xiang, Ph.D. M.D. 5136366303 jing.xiang@cchmc.org

Locations
United States, Ohio
MEG Recruiting
Cincinnati, Ohio, United States, 45229
Contact: Yingying Wang, Master    513-636-3495    yingying.wang@cchmc.org   
Sponsors and Collaborators
Children's Hospital Medical Center, Cincinnati
University of Cincinnati
Investigators
Study Director: Jing Xiang, Ph.D M.D. Children's Hospital Medical Center, Cincinnati
Study Director: Douglas Rose, M.D Children's Hospital Medical Center, Cincinnati
  More Information

Additional Information:
Publications:

Responsible Party: Jing Xiang, Director of MEG Research, Children's Hospital Medical Center, Cincinnati
ClinicalTrials.gov Identifier: NCT00600717     History of Changes
Other Study ID Numbers: IRB 06-04-23
Study First Received: June 14, 2007
Last Updated: February 8, 2012
Health Authority: United States: Institutional Review Board

Keywords provided by Children's Hospital Medical Center, Cincinnati:
Magnetoencephalography(MEG)
Sensorimotor
Auditory
Visual
Language
This study focuses on normal MEG data

ClinicalTrials.gov processed this record on October 29, 2014