Monoamine Transporter Function and Autonomic Regulation During Psychodynamic Psychotherapy
Outcome of psychodynamic psychotherapy measured by [123I] nor-B-CIT SPET imaging
Background Psychodynamic psychotherapy is a widely practised form of psychotherapy in the treatment of depression. There is evidence that serotonin transporter (SERT) densities are altered in depression. Preliminary observations have suggested that SERT function may recover in connection with dynamic psychotherapy.
The objective was to determine whether SERT densities change in relation to clinical recovery during psychodynamic psychotherapy.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
DNA, creatine, B-vitamin,BP from blood samples.
|Study Start Date:||January 2000|
|Study Completion Date:||December 2008|
Method Twenty six drug-naïve currently depressed (moderate/severe) patients with no previous treatment were recruited for the study. The baseline study included a group of 18 healthy controls. The patients were randomised into psychotherapy and waiting-list control groups. For controls, psychotherapy was started after a 6-month waiting period. [123I] nor-B-CIT SPET imaging was performed at baseline and after 12 months of psychotherapy. For the controls, additional imaging was performed after the 6-month waiting period.
|Principal Investigator:||Pirjo Saarinen, Ph.D.||Kuopio University Hospital|
|Study Director:||Johannes Lehtonen, Ph.D||Kuopio University Hospital|
|Study Chair:||Lehto Soili, MD||Kuopio University Hospital|
|Study Chair:||Minna Valkonen-Korhonen, Ph.D||Kuopio University|
|Study Chair:||Pasi Ahola, MD||Kuopio University|
|Study Chair:||Mikko Joensuu, MD||Kuopio University Hospital|
|Study Chair:||Tommi Tolmunen, Ph.D.||Kuopio University Hospital|