A Biochip for Rapid Diagnosis of Complicated Urinary Tract Infection
The purpose of this proposal is clinical validation of an electrochemical biochip for rapid pathogen identification and antibiotic susceptibility determination.
Urinary Tract Infections
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||A Biochip for Rapid Diagnosis of Complicated Urinary Tract Infection|
- detect pathogens in urine [ Time Frame: ongoing ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||July 2007|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
Patients at risk for urinary tract infections. No interventions.
Point-of-care identification of pathogens and determination of antibiotic susceptibility will significantly improve the clinical management of UTI. We have previously developed a biochip based on microfabrication technology capable of rapid detection of pathogens. The specific objectives of the current proposal are: 1) Determination of microbial constituents in spinal cord injury (SCI) patients and development of additional species-specific probes against these pathogens; 2) Development of a rapid antibiotic susceptibility and molecular pyuria assay using the electrochemical biochip; and 3) Clinical validation of the biochip as a diagnostic test for UTI.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00591240
|United States, California|
|VA Palo Alto Health Care System|
|Palo Alto, California, United States, 94304-1290|
|Principal Investigator:||Joseph C. Liao, MD||VA Palo Alto Health Care System|