Microbial Community Composition and Dynamics in Lungs of Cystic Fibrosis Sibling Pairs
The purpose of this study is to identify all the bacterial species present in the respiratory tracts of patients with Cystic Fibrosis (CF), and to connect them with clinical information. Traditional culture methods of throat swab and sputum samples can only identify the most prevalent bacteria in samples, those of which there are over about 5 million bacteria per teaspoon. A recently developed method has been found to be more sensitive and can detect up to several hundred bacterial species in throat swab or sputum sample of individual CF patients.
|Study Design:||Observational Model: Family-Based
Time Perspective: Prospective
|Official Title:||Microbial Community Composition and Dynamics in Lungs of Cystic Fibrosis Sibling Pairs|
- To identify all the bacterial species present in the respiratory tracts of patients with Cystic Fibrosis (CF). [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
sputum or throat culture
|Study Start Date:||October 2007|
|Study Completion Date:||March 2009|
|Primary Completion Date:||March 2009 (Final data collection date for primary outcome measure)|
This study does not include testing of any investigational drugs and this is a noninvasive study requiring only a sputum/swab sample paired with information contained in the routine clinic letters and laboratory results your CF physicians obtain at your regular clinic visits.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00590330
|United States, Massachusetts|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Thomas Martin, MD||Children's Hospital Boston|