Asthma in the Delta Region of Arkansas: Characterization of Disease and Impact of Environmental Factors (ADRA)
The purpose of the study is to evaluate asthma and examine the homes of children with asthma living in rural areas of the state. This study is being done to give investigators more information about the presence of allergens and endotoxin in the homes of children with asthma living in the delta region of Arkansas.
|Study Design:||Observational Model: Ecologic or Community
Time Perspective: Cross-Sectional
|Official Title:||Asthma in the Delta Region of Arkansas: Characterization of Disease and Impact of Environmental Factors|
- Asthma morbidity data will be analyzed to examine relationships between home environment factors and morbidity outcomes such as symptom frequency, medication use, healthcare utilizations and decreased activity. [ Time Frame: Three years ] [ Designated as safety issue: No ]
- The study will yield preliminary and feasibility data critical for designing future large-scale asthma studies among high-risk populations. [ Time Frame: Three years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Optional buccal swab samples will be obtained from participants. This is done by touching the inside of the participant's cheek to collect a sample of the cells in his/her mouth with a cotton swab type applicator.
|Study Start Date:||October 2006|
|Estimated Study Completion Date:||December 2014|
|Primary Completion Date:||December 2009 (Final data collection date for primary outcome measure)|
EU, LV, MA, EL, DU
The population will consist of 120 English-speaking participants ages 4-17 years from four rural schools with physician-diagnosed asthma or symptoms of asthma in the previous 12 months. As of June 2008, an additional rural school has been added to the population criteria, making a total of five rural schools.
Asthma is the most common chronic disease of children and disproportionately affects minority and low-income children. Current pediatric asthma research in this high-risk group focuses on children living in inner-city environments. Low-income, minority children with asthma from non-urban locales have not been studied extensively. The specific aims of the study will examine the impact of home environmental exposure to endotoxin on asthma severity and atopy status in the rural setting among predominately African American, low-income asthmatics. This study will answer several research questions. The first question involves the relationship between asthma severity and exposure to endotoxin among rural children at high risk for increased morbidity and mortality. Second, the relationship between atopy and endotoxin exposure has been the subject of recent debates among asthma researchers. The hygiene hypothesis suggest that the recent rise in atopic disease in Westernized societies is due to decreased microbial burden. Last data on atopy and aeroallergen exposure among high-risk rural asthmatics will be critical in the design and implementation of future intervention programs.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00590304
|United States, Arkansas|
|Arkansas Children's Hospital Research Institute|
|Little Rock, Arkansas, United States, 72202|
|Principal Investigator:||Tamara T. Perry, M.D.||University of Arkansas|